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Diss Factsheets
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EC number: 275-965-6 | CAS number: 71735-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- After defined time intervals aliquots of the test solutions were injected into the HPLC system. For calculation the peak area of the main peak was used.
- Buffers:
- pH 4: Bernd Kraft, citric acid, sodium chloride, sodium hydroxide
pH 7: Bernd Kraft; phosphate mixture
pH9: Bernd Kraft, boric acid, potassium chloride, sodium hydroxide - Estimation method (if used):
- Assuming first order reactions, hydrolysis rates and half-lives for other temperatures can be calculated at pH4, pH 7 and pH 9 according to Arrhenius equation. By plotting the natural logarithm of the rate constant against the reciprocal of the temperature (K), the rate constans and half-lives at 20°C and 25°C were obtained by extrapolation.
- Transformation products:
- not specified
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- 15 269 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 6 548 h
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 6 314 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 2 808 h
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 108 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- 52 h
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- No significant hydrolysis products could be elucidated in any test (ph 4, 7, 9) under the analytical conditions applied. It was observed that additional peaks of the test item besides the main peak differed in the peak areas during the hydrolysis test. But there was no linear correlation observable between the main peak and the additional peaks. The peak at about 2.6 min which can be observed in some tests is also detectable in the blank.
The degradation reaction measured at pH 4, 7, 9 can be assumed to be first or pseudo-first order. Due to this the half-lives for 20°C and 25° can be calculated. - Conclusions:
- In contact with water the substance will hydrolyse slowly. The slowest reaction is expected in an acidic environment.
Reference
Description of key information
In contact with water the substance will hydrolyse slowly. The slowest reaction is expected in an acidic environment.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 117 d
- at the temperature of:
- 25 °C
Additional information
The results of a hydrolysis study according to OECD guideline 111 show that the test substance was unstable at higher pH and elevated temperatures.
(70 - 80 °C), resulting in half-lives 74 to 67 hours, respectively. At 25 °C the half-life at pH 4 was 2665 hours and > 1 year at pH values of 7 and 9.
The degradation reaction measured by pH 4, pH 7 and pH 9 can be assumed to be pseudo-first order.
The calculated half-lives for 20°c and 25°C are:
20°C | 25°C | |
pH4 | 15269h (636.2d) | 6548h (272.8d) |
pH7 | 6314h (236.1d) | 2808 h (117d) |
pH9 | 108h (4.5d) | 52h (2.2d) |
No significant hydrolysis products could be elucidated in any test (pH 4, pH 7 and pH 9) under the analytical conditions applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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