Registration Dossier
Registration Dossier
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EC number: 203-518-7 | CAS number: 107-75-5
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: In vitro test with uncertain relevance and without formal validation
Data source
Reference
- Reference Type:
- publication
- Title:
- Molecular Structure-Teratogenicity Relationships of some Fragrance Additives
- Author:
- Abramovici A, Rachmuth-Roizman P
- Year:
- 1 983
- Bibliographic source:
- Toxicology 29: 143-156
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 7-hydroxycitronellal
- EC Number:
- 203-518-7
- EC Name:
- 7-hydroxycitronellal
- Cas Number:
- 107-75-5
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 7-hydroxy-3,7-dimethyloctanal
- Details on test material:
- - Name of test material (as cited in study report): hydroxycitronellal
- Analytical purity: pure grade chemical
- Supplier: Eastman Org. Chem., Rochester, New York
Constituent 1
Test animals
- Species:
- other: hen
- Strain:
- other: white Leghorn X Rhode Island red strain
Administration / exposure
- Route of administration:
- other: suprablastodermical
- Vehicle:
- olive oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 12 days
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.25, 0.50, 1.25, 5.00, 12.5 µM/embryo
Basis:
- No. of animals per sex per dose:
- total 245
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Result: Under the conditions of the study the test substance induced lethality and malformations in chick embryos.
Control:
--------
Olive oil induced 17.8 % lethality, while the frequency of malformations (7.9 %), almost non-specific ones, was in the range of spontaneous malformations.
Hydroxycitronellal:
---------
Dose uM/embryo / % of abnormal embryos /
-----------------------------------------------------
0.25 / 12.5 /
0.50 / 37.5 /
1.25 / 32.2 /
5.00 / 24.1 /
12.50 / 23.07 /
-----------------------------------------------------
Dose uM/embryo / % of mortality /
-----------------------------------------------------
0.25 / 18.7 /
0.50 / 50.0 /
1.25 / 90.3 /
5.00 / 60.8 /
12.50 / 89.6 /
25.00 / 92.3 /
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Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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