Registration Dossier
Registration Dossier
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EC number: 203-518-7 | CAS number: 107-75-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed not acc. to current standart protocols, limited analytical investigations
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study was performed acc. internal BASF method, which was in large part equivalent to the inhalation hazard test
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- 7-hydroxycitronellal
- EC Number:
- 203-518-7
- EC Name:
- 7-hydroxycitronellal
- Cas Number:
- 107-75-5
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 7-hydroxy-3,7-dimethyloctanal
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Hydroxycitronellal (HCA); 3.7-Dimethyl-7-hydroxyoctanol-1
- Physical state: liquid
- Purity: approx. 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: generated by bubbling 200 l/h air at 20°C or 40°C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- It was intended to determine the nominal concentration of the athmosphere generated on the basis of the weight difference of the substance column before and after the exposure period. However, due to increased weights after exposure, determination of concentration is not valid.
- No. of animals per sex per dose:
- 6 (20°C); 6 (40°C)
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of weighing: prior to begin of study, day 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
- Mortality:
- 20°C: 0/12 deaths
40°C: 0/12 deaths - Body weight:
- no evident effect observed
- Gross pathology:
- 20°C: no effects observed
40°C: bronchitis in 2 animals, which was stated to be "not caused by the substance" - Other findings:
- No substance related findings were observed
Applicant's summary and conclusion
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