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Diss Factsheets
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EC number: 246-309-6 | CAS number: 24549-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
According to the findings of the subacute oral toxicity study a LOAEL of 221 mg/kg body weight can be determined, but with the restriction that the study has limitations concerning dosage and observation parameters compared to the guideline study. No classification is required according to the available data base.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- LOAEL
- 221 mg/kg bw/day
Additional information
Repeated dose toxicity: oral
In a subacute toxicity study male Fischer 344 rats were treated orally via gavage needle with 2-methyl-6-ethylaniline (221 mg/kg and day). The rats were treated for 5, 10 or 20 days. No clinical signs and mortality were seen in the 2-methyl-6-ethylaniline (MEA) treated rats. The body weight of the treated rats was not significant different to the concurrent control rats. No significant differences in organ weights of liver, kidney and spleen were found in the treated rats compared to the control group. In addition no histopathological lesions were found in the liver, esophagus, trachea, thyroid, para-thyroid, urinary bladder, and spleen after MEA treatment, whereas a hypercellularity in the bone marrow was seen after MEA treatment. The effect was significant different from control on day 10, but not on day 20 (Short 1983). According to the findings of this study a LOAEL of 221 mg/kg body weight can be determined, but with the restriction that the study has limitations concerning dosage and observation parameters compared to the guideline study. No classification is required according to the available data base.
Repeated dose: dermal
There are no data available for the dermal repeated dose toxicity.
Repeated dose: inhalation
There are no data available for the inhalation repeated dose toxicity.
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: bone marrow
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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