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EC number: 246-309-6 | CAS number: 24549-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Different toxicokinetic studies with rats showed that MEA is readily absorbed independent of the application route (ECB 2000 b). The test substance is readily taken up into the general circulation and is rapidly excreted, mainly with the urine (76% to 93 %) (ECB 2000 a, ECB 2000 b, Marco 1985).
Key value for chemical safety assessment
Additional information
Different toxicokinetic studies with rats showed that 2 -methyl-6-ethylaniline (MEA) is readily absorbed independent of the application route (ECB 2000 b). The test substance is readily taken up into the general circulation and is rapidly excreted, mainly with the urine (76% to 93 %) (ECB 2000 a, ECB 2000 b, Marco 1985). One major urine metabolic metabolite was identified as the sulfate ester conjugate of 2-ethyl-4-hydroxy-6-methyl aniline. Only a minority of the test substance is eliminated in the feces (2-6%) (ECB 2000 b, Marco1985). About 5 %, 2 %, and less than 1 % of the dose applied remained in or on the animal after dermal (48 hours), inhalation (48 hours) and oral (72 hours) application (ECB 2000 b). The recovery of the test substance in the tissues was highest in livers, kidneys, blood components, fat, adrenals and thyroids. No apparent sex difference in blood content and excreta of the test substance were found (ECB 2000 a).
Discussion on bioaccumulation potential result:
Different toxicokinetic studies with rats showed that MEA is readily absorbed independent of the application route (ECB 2000 b). The test substance is readily taken up into the general circulation and is rapidly excreted, mainly with the urine (76% to 93 %) (ECB 2000 a, ECB 2000 b, Marco 1985). One major urine metabolic metabolite was identified as the sulfate ester conjugate of 2-ethyl-4-hydroxy-6-methyl aniline. Only a minority of the test substance is eliminated in the feces (2-6%) (ECB 2000 b, Marco1985). About 5 %, 2 %, and less than 1 % of the dose applied remained in or on the animal after dermal (48 hours), inhalation (48 hours) and oral (72 hours) application (ECB 2000 b). The recovery of the test substance in the tissues was highest in livers, kidneys, blood components, fat, adrenals and thyroids. No apparent sex difference in blood content and excreta of the test substance were found (ECB 2000 a).
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