Registration Dossier
Registration Dossier
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EC number: 248-003-8 | CAS number: 26787-78-0
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Data waiving (other justification): In accordance with column 2 of REACH annex VIII, the adsorption/desorption screening test does not have to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption. The test substance has a low octanol water partition coefficient (0.87).
Supporting study: EPI Suite (US EPA) Calculation. Koc = 108.4 L/kg and log Koc = 2.035 at 20ºC.
Key value for chemical safety assessment
- Koc at 20 °C:
- 108.4
Additional information
Data waiving (other justification): In accordance with column 2 of REACH annex VIII, the adsorption/desorption screening test does not have to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption. The test substance has a low octanol water partition coefficient (0.87).
Supporting study: The calculated Koc is 108.4 L/kg and log Koc is 2.035 (EPI Suite, KOCWIN v2.00, MCI method).
Supporting study: An adsorption study to sludge was conducted with amoxicillin by Andreozzi et al (2004). The adsorption and desorption rates of amoxicillin onto sludge were determined to be 0.0437 h-1 and 0.0778 h-1, respectively, at 25ºC. From obtained results it is evident that both biodegradation and adsorption processes can play an important role in the transformation and removal of amoxicillin from the aquatic environment, the former being the faster one.
Supporting study: In the study performed by Githingi et al. (2010) it was stated that amoxicillin decreased in sorption with pH increase. The sorption behaviour can be explained by their carboxylic acid and amine functional groups, giving them amphoteric properties. At high pH, the carboxylic group dissociates creating net negative charges on the molecules. At low pH, the amine group take up hydrogen atoms leading to a net positive charge.
[LogKoc: 2.035]
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