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Diss Factsheets
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EC number: 429-290-0 | CAS number: 3380-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 429-290-0
- EC Name:
- -
- Cas Number:
- 3380-30-1
- Molecular formula:
- C12 H8 Cl2 O2
- IUPAC Name:
- 5-chloro-2-(4-chlorophenoxy)phenol
- Details on test material:
- - Name of test material (as cited in study report): FAT 80'220/B = DCPP
- Physical state: White emulsion
- Analytical purity: 0.3% DCPP (w/v)
- Lot/batch No.: 98/06/03
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- pig
- Strain:
- other: not applicable
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not applicable since in vitro assay using ears from adult pigs obtained from an abattoir.
Administration / exposure
- Type of coverage:
- other: not applicable
- Vehicle:
- other: DCPP was tested as O/W formulation with Tinosan® HP 100 (Tinosan® HP 100 contains 29.4% DCPP)
- Duration of exposure:
- 0.5 and 24 h
- Doses:
- 0.3% DCPP (w/v)
30 µg DCPP/cm² skin - No. of animals per group:
- not applicable
- Control animals:
- no
- Remarks:
- , not applicable
- Details on in vitro test system (if applicable):
- The pig ears were washed under running water and badly damaged ears rejected. The remaining ears were shaved with animal clippers and whole skin (epidermis + dermis) was separated from the cartilage using a scalpel. The skin samples were immersed in water at 60°C for 55-60 seconds and the epidermis teased away from the dermis. Each epidermal membrane was given an identifying number and stored frozen on aluminium foil.
Discs of approximately 3.3 cm diameter of prepared skin membrane from at least three subjects were mounted, dermal side down, in diffusion cells held together with individually numbered clamps.
For determination of membrane integrity, The donor and receptor chambers of the cells were filled with physiological saline (approx 0.9% w/v sotdium chloride in water) and placed in a water bath maintained at 32 ± 1 °C.
The integrity of the membranes was determined by measurement of the electrical resistance across the skin membrane.
- Volume applied 25.4 µL
- Size of test site 2.54 cm²
- Exposure period 0.5, 24 h
- Receptor fluid 25% Ethanol in pH 7 phosphate buffered saline
- Samples Receptor fluid, tape strips, washings.
- Sampling time
- - Receptor fluid: 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, and 24 h
- - Tape strips, remaining receptor fluid and washings: at study termination (24 h).
Results and discussion
Percutaneous absorptionopen allclose all
- Dose:
- 0.3% DCPP
- Parameter:
- percentage
- Absorption:
- 2 - 9 %
- Remarks on result:
- other: 0.5 h exposure
- Remarks:
- Receptor fluid: 6.22%, epidermis: 2.87%, potential absorption: 9.09%
- Dose:
- 0.3% DCPP
- Parameter:
- percentage
- Absorption:
- 15 - 34 %
- Remarks on result:
- other: 24 h exposure
- Remarks:
- Receptor fluid: 19.2%, epidermis: 15.2%, potential absorption: 34.4%
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.