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Diss Factsheets
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EC number: 429-290-0 | CAS number: 3380-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study on Triclosan, suitable for read-across.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 796.3140 (Anaerobic Biodegradability of Organic Chemicals)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triclosan
- EC Number:
- 222-182-2
- EC Name:
- Triclosan
- Cas Number:
- 3380-34-5
- IUPAC Name:
- 5-chloro-2-(2,4-dichlorophenoxy)phenol
- Details on test material:
- - Name of test material (as cited in study report): Triclosan
- Lot/batch No.: # 21738-037
- Radiochemical purity (if radiolabelling): 94.8 %
- Specific activity (if radiolabelling): 15 µCi/mg
Constituent 1
Study design
- Oxygen conditions:
- anaerobic
- Inoculum or test system:
- anaerobic sludge
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): primary (anaerobic) sludge from Nut Island Wastewater Treatment Plant, Quincy Massachusetts, USA
- Pretreatment: 2 mm mesh sieved
- Concentration of sludge: 3000000 cfu/mL - Duration of test (contact time):
- 147 d
Initial test substance concentration
- Initial conc.:
- 200 µg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- Details on study design:
- TEST CONDITIONS
- Composition of medium: 95 mL of prepared inoculated medium and the appropriate amount of test article or reference material
- Test temperature: 35 ± 1 °C
TEST SYSTEM
- Culturing apparatus: 150-mL Wheaton serum bottle capped with a butyl rubber serum-bottle stopper
- Number of culture flasks/concentration: 1
SAMPLING
- Sampling frequency: concentration of [14C]-Triclosan remaining in the test article vessels was determined on days 0, 7, 14, 21, 28, 42, 56, 70, 91, 119 and 147.
- Sampling method: 3 vessels were sacrificed for analysis by HPLC-RAM
Results and discussion
% Degradation
- Parameter:
- % degradation (radiochem. meas.)
- Value:
- < 10
- Sampling time:
- 147 d
- Details on results:
- No concrete evidence for the biodegradation of Triclosan under anaerobic conditions was observed.
- The radioactivity distribution of extracts from test vessels receiving 200 µg/L Triclosan indicated that 90-92 % (mean: 91 %, n = 3) of extractable residues remained as [14C]-Triclosan after 147 days of incubation with anaerobic inoculum, under anaerobic conditions. The percent extractable decreased steadily with time, but with no concomitant appearance of Triclosan metabolites it is unlikely that mineralization to CO2 and methane occurred.
- Microbial analysis of the sludge during the study indicated that the sludge microbes were still viable.
- Testing performed with a reference material, ethanol, in the same anaerobic test solution resulted in mean cumulative gas production of 69 to 310% of theoretical during the 147-day test, when corrected for blank gas production. The high gas production may have resulted from respiratory stimulation of the microbes by the ethanol, or by consumption of carbon contaminants in the glass bottles; nevertheless, the reference article performance indicates an active microbial community capable of degrading simple organic compounds.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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