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EC number: 204-984-4 | CAS number: 130-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: combined repeated dose and reproduction / developmental screening;fertility
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- 293 mg/kg bw/day (actual dose received); Estimation for NOAEL reproductive toxicity for Cas no:130-26-7
- Author:
- Sustainabilty Support Services Europe (AB)
- Year:
- 2 014
- Bibliographic source:
- SSS QSAR Prediction Team
Materials and methods
Test guideline
- Guideline:
- other: OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test);OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test) (study number
- Principles of method if other than guideline:
- Prediction using category approach; QSAR Toolbox 3.1; Read Across; 5 nearest analogues; Log Kow as descriptor
- GLP compliance:
- no
Test material
- Reference substance name:
- Clioquinol
- EC Number:
- 204-984-4
- EC Name:
- Clioquinol
- Cas Number:
- 130-26-7
- Molecular formula:
- C9H5ClINO
- IUPAC Name:
- 5-chloro-7-iodoquinolin-8-ol
- Details on test material:
- SMILES:c1(I)c(O)c2c(c(Cl)c1)cccn2
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 30, 100, 300, 1000 mg/kg
Basis:
- No. of animals per sex per dose:
- 12
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 293 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No effects were observed
- Remarks on result:
- other: not specified
Target system / organ toxicity (P0)
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
Results: F2 generation
Effect levels (F2)
- Remarks on result:
- not measured/tested
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: NOEL,"NOEL reproductive/developmental toxicity","NOAEL
reproduction","NOEL overall","NOAEL developmental","NOAEL for parental
toxicity","NOAEL for reproductive toxicity",NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a"
or "b" or "c" or "d" or "e" or "f" or "g" )
and ("h"
and (
not "i")
)
)
and ("j"
and "k" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Phenols (Acute toxicity) by
US-EPA New Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Aromatic heterocyclic halide AND
Aryl AND Aryl halide AND Fused carbocyclic aromatic AND Fused
heterocyclic aromatic AND Phenol AND Pyridine AND Quinoline/
Isoquinoline by Organic functional groups
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aromatic heterocyclic halide AND
Aryl halide AND Overlapping groups AND Phenol AND Quinoline/
Isoquinoline by Organic functional groups (nested)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Alcohol, olefinic attach [-OH]
AND Aromatic Carbon [C] AND Aromatic Nitrogen AND Chlorine, aromatic
attach [-Cl] AND Chlorine, olefinic attach [-Cl] AND Hydroxy, aromatic
attach [-OH] AND Iodide, aromatic attach [-I] AND Olefinic carbon [=CH-
or =C<] AND Oxygen, one aromatic attach [-O-] by Organic functional
groups (US EPA)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Aromatic compound AND Aryl
chloride AND Aryl halide AND Aryl iodide AND Halogen derivative AND
Hydroxy compound AND Phenol by Organic functional groups, Norbert Haider
(checkmol)
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 16 - Oxygen O AND Group 17 - Halogens Cl AND
Group 17 - Halogens F,Cl,Br,I,At AND Group 17 - Halogens I by Chemical
elements
Domain
logical expression index: "g"
Similarity
boundary:Target:
c1(I)c(O)c2c(c(Cl)c1)cccn2
Threshold=50%,
Dice(Atom centered fragments)
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as No alert found by rtER Expert
System ver.1 - USEPA
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Alkylphenols OR Parabens OR
Phenylphenols by rtER Expert System ver.1 - USEPA
Domain
logical expression index: "j"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.39
Domain
logical expression index: "k"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.48
Applicant's summary and conclusion
- Conclusions:
- The NOAEL (No observed adversed effect level) of clioquinol was observed at a dose level of 293 mg/kg/day.
- Executive summary:
WoE Summary for Cas: 130-26-7
The NOAEL value of clioquinolisestimated to be 293 mg/kg bw/day (actual dose received) for duration of 14 days on rat using the toolbox version 3.2.
The data is estimated to be based on the data summarized below
Sr no.
CAS no
End point
Value
Species
Doses
Duration
Effects
Remarks
1
118-79-6
NOAEL reproduction
1000mg/kg bw/day (actual dose received)
Rat
0, 30, 100, 300, 1000 mg/kg
14 days
No effect was seen on hematological parameters. High tissue weights for livers and kidneys
118-79-6
NOAEL reproduction
300 mg/kg bw/day (actual dose received)
Rat
0, 30, 100, 300, 1000 mg/kg
14 days
No adverse effects were observed
2
128-39-2
NOAEL
150 mg/kg bw/day (actual dose received)
Rat
30, 150, 750 mg/kg bw/day
14 days
No teratogenic effect was observed at external examination and necropsy
3
80-09-1
NOAEL for reproductive toxicity
60 mg/kg bw/day (actual dose received
Rat
0, 10, 60 and 300 mg/kg bw/day
males 45 days, females from 14 days
No effects were observed on estrous cycles, fertility index, number of implantations, implantation index, number of live births and number of live offspring
4
NOEL reproductive/developmental toxicity
1000 mg/kg bw/day (actual dose received)
Rat
0, 40, 200, 1000 mg/kg bw./day
Male:42 days &female:28 days
No effects on mortality, food consumption, organ weights, number of mated pairs, number of copulated pairs, copulation index, number of pregnant animals
The above table consist of various reproductive toxicity studies available for the read across substances for CAS: 130-26-7.Based on the above results it can be observed that NOAEL or NOEL values are in the range of 60 - 1000 mg/kg bw./day and .The no effects observed on the above doses are listed as follows.
· Effect was seen on hematological parameters. weights of livers and kidneys
· teratogenic effect was observed at external examination and necropsy
· estrous cycles, fertility index, and number of implantations, implantation index, number of live births and number of live offspring.
· mortality, food consumption, organ weights, number of mated pairs, number of copulated pairs, copulation index, number of pregnant animals
Thus based on above discussion it can be concluded that estimated value 293 mg/kg bw/day for the substance (CAS: 130-26-7) is more closed to 300 mg/kg bw/day in sub-acute duration for rat
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