Clioquinol

Short-term toxicity to fish

Description of key information

The lethal concentration (LC50) value ofclioquinolin fish[Carassius auratus (Goldfish)] in a 96 hr study on mortality effect was found to be 103.7406 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

103.741 mg/L

Additional information

No. of studies were reviewed for Short-term toxicity to fish from reliable sources having Klimisch rating 2 .

The summary of the results are presented below

 

Sr.No	Endpoint	Effect values	Basis for effect	Duration	Species	Sources
1	LC50	103.74 mg/L	Mortality	96 hrs.	Carassius auratus	Predicted data for Target Cas:130-26-7
2	LC50	10 mg/L	Mortality	24 hrs.	Ptychocheilus oregonensis	Publication data for Target Cas:130-26-7
3	LC50	10 mg/L	Behaviour	24 hrs.	Oncorhynchus kisutch	Publication data for Target Cas:130-26-7

 

 

Based on the studies summarized in the above table for the target substance clioquinol and the read across substance,the endpoint value was found to vary between lethal concentration between LC50 = 10 mg/L to 103 mg/L in a 24hr to 96 hrs.study on the basis of mortality effect. Based on the LC50 values, the substance may qualify for the aquatic classification .

Since the BCF value of clioquinol reported was not >= 500 as well as the substance was found to be rapidly degradable.Thus considering the from CLP Criteria for aquatic classification of the substance , it is concluded that Clioquinol could not exhibit short term toxicity to fish .