Registration Dossier
Registration Dossier
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EC number: 252-471-9 | CAS number: 35265-04-4
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
In the test conditions, 2-(sec-butylamino)ethanol presented no inherent, primary biodegradability.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The aerobic biodegradation of 2-(sec-butylamino)ethanol has been assessed during 28 days according to the OECD 301F guideline and GLP requirements (Feil, 2009). Based on the ThOD(NH4) the percentage biodegradation of 2-(sec-butylamino)ethanol reached 12% (mean) after 28 days of incubation. Taking the occurrence of nitrification into account 2-(sec-butylamino)ethanol reached a percentage biodegradation of 9% (mean). The substance was considered as not readily biodegradable. All the validity criteria were fulfilled. Another biodegradation test according to OECD 310 and GLP requirements has been performed (Xiaoqian, 2012). No degradability of the test substance was observed during the test.
In addition, the study of inherent biodegradation of 2 -(sec-butylamino)ethanol was performed by the modified MITI Test (II) according to OECD 302C and GLP requirements (Xiaoqian, 2011). The calculated percentage biodegradation of 2-[(1-methylpropyl)amino]ethanol based on the BOD was 8.71% in the 28th day. It showed that this test substance has no ultimate biodegradability. The percentage primary biodegradation of test substance in the 28th day was 1.16% based on the calculated results of UPLC-MS analysis. The test substance has no primary biodegradability (no change in molecular structure). According to the cumulative oxygen consumption, the mean degradation percentages of the reference substance were 70.30 % and 72.73 % after 7 and 14 days, respectively. Hence, the test is considered to be valid.
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