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EC number: 271-234-0 | CAS number: 68526-85-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Remarks:
- combined repeated dose and reproduction / developmental screening
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- publication
- Title:
- Human health risk assessment of long chain alcohols
- Author:
- Veenstra G, Webb C, Sanderson H, Belanger SE, Fisk P, Nielsen A, Kasai Y, Willing A, Dyer S, Penney D, Certa H, Stanton K, Sedlak R.
- Year:
- 2 009
- Bibliographic source:
- Ecotoxicology and Environmental Safety
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dodecan-1-ol
- EC Number:
- 203-982-0
- EC Name:
- Dodecan-1-ol
- Cas Number:
- 112-53-8
- Molecular formula:
- C12H26O
- IUPAC Name:
- dodecan-1-ol
- Reference substance name:
- 1-Dodecanol
- IUPAC Name:
- 1-Dodecanol
- Details on test material:
- Dodecanol is a 12 carbon long chain alcohol.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Male rats were exposed for a 37 days including the mating period.
Females rats were exposed from prior to mating through natural littering. Exposure ended at final sacrifice at day 5 postnatally. - Frequency of treatment:
- Continuous
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1500 ppm (100 mg/kg/bw/day)
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
7500 ppm (500 mg/kg/bw/day)
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
30000 ppm (2000 mg/kg/bw/day)
Basis:
nominal in diet
- No. of animals per sex per dose:
- 12
- Control animals:
- yes
Results and discussion
Results of examinations
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- no effects observed
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- reduction in mean white blood cell count for male rats (15%, 38%, and 32% reduction in the low-, mid-, and high-dose groups, respectively)
- Clinical biochemistry findings:
- effects observed, treatment-related
- Description (incidence and severity):
- 38% decrease in free cholestrol reported for mid-dose males; a 46% decrease in triglycerides in high-dose males)
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
Effect levels
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- < 1 500 ppm
- Basis for effect level:
- other: hematological (WBC) changes
- Dose descriptor:
- NOAEL
- Effect level:
- <= 30 000 ppm
- Sex:
- male/female
- Basis for effect level:
- other: No effect in macroscopic and histological examinations. No effect on BW, weight gain, food consumption and food efficiency.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Veenstra et al (2009) indicated the effects on white blood cell counts were of uncertain toxicologic significance because no alterations in differential cell counts were observed.
The observed changes in plasma chloesterol in mid-dose males were attributed to chance based on two outlier values included in the calculation of plasma cholestrol.
Veentra et al speculated the marginal effects on plasma cholestrol and triglyceride may be indicative of some biological effect on liver, but also indicated diet composition differences may have confounded some measured parameters.
Applicant's summary and conclusion
- Executive summary:
24 rats (12 male and 12 female) were used in each dose group, which received 1-Dodecanol in the diet in concentrations of 0, 1500, 7500, and 30000 ppm (ca. 0, 100, 500 and 2000 mg/kg/bw/day) for a period of 37 days or longer. 1-Dodecanol had no influence on body weight, weight gain, food consumption and food efficiency in either sex at the doses employed. All pathological and histopathological findings were considered incidental, and not related to the dosing. The total number of white blood cells was reduced dose dependently, but no differences in differential count of the white blood cells could explain this effect. Mean white blood cell counts were 7.0 in the control group, 5.9 at 100 mg/kg, 4.3 (P<0.001) at 500 mg/kg and 4.7 (P<0.01) in the 2000 mg/kg groups. A statistically significant reduction was observed in plasma free cholesterol in the 500 mg/kg/bw/day group (from a mean of 0.18 in controls to 0.11 (P<0.05), and in triglyceride in the 2000 mg/kg/bw/day group( from a mean of 0.58 in controls to 0.31 (P<0.01). The reduction in free cholesterol seen in the 500 mg/kg group may be explained by two outliers with much lower concentrations than the remainder of that group.
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