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EC number: 271-234-0 | CAS number: 68526-85-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 402: pre-GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
- Reference Type:
- publication
- Title:
- Acute toxicity of a homologous series of branched chain primary alcohols
- Author:
- Scala RA and Burtis EG
- Year:
- 1 973
- Bibliographic source:
- Am Ind Hyg Assoc J 34:493-499
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C9-11-iso-, C10-rich
- EC Number:
- 271-234-0
- EC Name:
- Alcohols, C9-11-iso-, C10-rich
- Cas Number:
- 68526-85-2
- Molecular formula:
- CnH2n+1OH (n = 9 to 11)
- IUPAC Name:
- Branched alcohols, C9-11, C10 rich
- Details on test material:
- - Name of test material (as cited in study report): MRD-59-13
- Physical state: clear liquid
- Analytical purity: assumed to be 100%
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No information provided.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No information provided.
- Duration of exposure:
- 24 hours
- Doses:
- 100, 316, 1000 or 3160 ul/kg (83.8, 264, 838, or 2648 mg/kg)
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 1, 4, and 24 hours after application and once daily thereafter for 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3.16 mL/kg bw
- Mortality:
- None
- Clinical signs:
- other: Following removal of the gauze, the skin area showed mild to moderate erythema and edema. All symptoms subsided within 1 to 3 days. At the time of sacrifice, animals in the high dose group exhibited slight erythema, desquamation, blanched areas, necroti
- Gross pathology:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 for isodecanol is >2648 mg/kg.
- Executive summary:
The dermal toxicity and irritative properties of isodecanol were evaluated in rabbits exposed to 100, 316, 1000 or 3160 ul/kg (83.8, 264, 838, or 2648 mg/kg) via an occluded patch for 24 hours. The animals were observed for gross effects at 1, 4, and 24 hours after application and once daily thereafter for 7 days. All animals survived dosing. Most animals exhibited slight signs of dermal irritation with severity increasing in a dose-related manner. Most signs of dermal irritation were resolved within 1-3 days in the two lower dose groups. At the time of sacrifice the exposed skin area of all animals generally showed atonia and desquamation. In addition, the animals at the 3160, ul/kg level showed blanched areas, necrotic areas, and a coriaceous condition. It is concluded that the LD50 is greater then 3160 ul/kg.
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