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Diss Factsheets
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EC number: 913-635-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary from a review article. Original reference could not be retireved.
- Justification for type of information:
- See attached file
- Reason / purpose for cross-reference:
- read-across: supporting information
- Principles of method if other than guideline:
- BOD elimination performance in a simulated STP under various sodium chloride conentrations.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
n.a. - Analytical monitoring:
- no
- Details on sampling:
- n.a.
- Vehicle:
- no
- Test organisms (species):
- activated sludge
- Test type:
- not specified
- Limit test:
- no
- Remarks on exposure duration:
- no data
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- no data
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 000 - 8 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: No detectable changes in activated sludge performance with intermittent feed (5 days per week). This is suggested as NOEC.
- Conclusions:
- No detectable changes in activated sludge performance at 5000–8000 mg/L with intermittent feed (5 days per week). This is suggested as NOEC.
- Endpoint:
- toxicity to microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary from a review article. Original reference could not be retireved.
- Principles of method if other than guideline:
- Viable counts of various frehswater bacteria incl. Bacillus subtilis and Escherichia coli under different sallinity.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
n.a. - Analytical monitoring:
- no
- Details on sampling:
- n.a.
- Vehicle:
- no
- Test organisms (species):
- Escherichia coli
- Details on inoculum:
- pure culture
- Test type:
- not specified
- Limit test:
- no
- Remarks on exposure duration:
- no data
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- no data
- Dose descriptor:
- NOEC
- Effect conc.:
- 292 - 584 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: stimulation of growth
- Remarks on result:
- other: the range describes the concentration where stimulation of growht occurs. This is suggested as NOEC.
- Conclusions:
- 292-584 mg/L sodium chloride stimulates growth for a series of relevant fresh water micro organisms.
- Endpoint:
- toxicity to microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
- Principles of method if other than guideline:
- Effect of different test material concentration on STP simulation units.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
n.a. - Analytical monitoring:
- no
- Details on sampling:
- n.a.
- Vehicle:
- no
- Test organisms (species):
- activated sludge
- Details on inoculum:
- pure culture
- Test type:
- not specified
- Limit test:
- no
- Remarks on exposure duration:
- no data
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- Unit 1: 8, 15, 320, 25, 30, 37.5, 40, 41, 42, 43, 44, 45
Unit 2: 5, 10, 15, 20 - Details on test conditions:
- no data
- Dose descriptor:
- EC10
- Effect conc.:
- <= 35 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: suspended solids and COD in effluent.
- Conclusions:
- EC10 (STP simulation)=35 g/L
- Executive summary:
Relative high concentration of sodium chloride (up to 35 g/L) have only a slight adverse impact on the performance of the activated sludge. Increase beyond 35 g/L caused abrupt increases in effluent suspended solid.
Referenceopen allclose all
Relative high concentration of sodium chloride (up to 35 g/L) have only a slight adverse impact on the performance of the activated sludge. Increase beyond 35 g/L caused abrupt increases in effluent suspended solid.
Description of key information
No experimental data are available to assess the toxicity of the reaction mass of calcium chloride and sodium chloride to aquatic microorganisms. No information is available for calcium chloride but some information is available for sodium chloride.
Available data gives a wide range of NOEC estimates in simulated sewage treatment plants. However, no data has been identified from experiments comparable to the standard activated sludge inhibition protocol. In the absence of such data, the lower end of the reported multi-day exposure NOEC for BOD performance (i.e. respiration inhibition) after intermittent dosing of sodium chloride is used as key value.
There is no information supporting the fact that calcium chloride should be more toxic than sodium chloride to auqatic microorganisms. Accordingly, the data on sodium chloride (NOEC(multiday) = 5000 mg/L) is considered to appropriately reflect the toxicity of the reaction mass of calcium chloride and sodium chloride.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 5 000 mg/L
Additional information
No experimental data are available to assess the toxicity of the reaction mass of calcium chloride and sodium chloride to aquatic plants other than alge. Nevertheless, some information is available for sodium chloride (NaCl).
Sodium chloride in waste water treatment plant is well investigated as waste water treatement plant based on the sea shore may use sea water to flush the system. Sodium chloride can stimulate growth in pure cultures up to concentrations of 300 -600 mg/L. Activated sludge in simulated sewage treatment plants have a high tolerance for sodium chloride in waste water. While the available data gives wide ranges for the NOEC concentration in simulated sewage treatment plants, no data has been identified from experiments comparable to the standard activated sludge inhibition protocol. In the absence of such data, the lower end of the reported multi day exposure NOEC for BOD performance (i.e. respiration inhibition) after intermittent dosing of sodium chloride is used as key value (i.e. NOEC(multiday) = 5000 mg/L).
Both sodium chloride and calcium chloride are expected to exhibit a toxic effect to aquatic plants due to their impact on osmotic pressure. There is no information supporting the fact that calcium chloride should be more toxic than sodium chloride to aquatic plants other than algae. This is supported by the fact that numerous experimental data found similar LC/EC50 values for other kinds of aquatic organisms (including fish, aquatic invertebrates and aquatic algae and cyanobacteria).
Accordingly, the data on sodium chloride is considered to appropriately reflect the toxicity of the reaction mass of calcium chloride and sodium chloride.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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