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EC number: 201-487-4 | CAS number: 83-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only as secondary citation available: guideline study and GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Naphthalene-1,5-diol
- EC Number:
- 201-487-4
- EC Name:
- Naphthalene-1,5-diol
- Cas Number:
- 83-56-7
- Molecular formula:
- C10H8O2
- IUPAC Name:
- naphthalene-1,5-diol
- Test material form:
- other: solid
- Details on test material:
- content : >99.9 %
batch no.820211/01
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Additional strain / cell type characteristics:
- other: S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Metabolic activation system:
- Liver S9-fraction fromphenobarbital/beta-naphthoflavone-induced rats was used as exogenous metabolic activation system
- Test concentrations with justification for top dose:
- Experiment I: 33-5000 µg/plate without and with S9-mix
Experiment II: 10-5000 µg/plate without and with S9-mix - Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- other: in accordance with the OECD guideline
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- Test concentrations were based on the level of toxicity in a preliminary toxicity test with strains TA98, TA100, TA102, TA
1535 and TA 1537 both without and with S9-mix. Toxicity was evaluated for 8 concentrations up to the prescribed
maximum concentration of 5000 μg/plate on the basis of a reduction in the number of revertant colonies
and/or thinning of the bacterial background lawn.
Since in this pre-experiment evaluable plates were obtained for five concentrations or more in all strains used
the pre-experiment is reported as experiment I.
Experiment I was performed with the direct plate incorporation method, incubation time: 48 h, with and without S9-mix
Experiment II with the pre-incubation method, incubation time: 48 h, with and without S9-mix
Negative and positive controls were in accordance with the OECD guideline. - Evaluation criteria:
- details not given , in accordance with the OECD Guideline
- Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and TA 102
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- other: yes, but details not given
- Additional information on results:
- Precipitation of 1,5-naphthalenediol was observed
in experiment I at 5000 μg/plate and in
experiment II at 2500 and 5000 μg/plate both without and with S9-mix.
Toxic effects
In experiment I without S9-mix toxic effects were observed at 2500 μg/plate for TA102 and
TA1535 and at 5000 μg/plate for TA98, TA100 and TA1537; with S9-mix at 5000 μg/plate
for TA100, TA102 and TA1535.
In experiment II without S9-mix toxicity was reported at
1000 μg/plate for TA98 and TA100 and at 2500 μg/plate for TA102; with S9-mix at 1000
μg/plate for TA102 and at 2500 μg/plate TA98.
Both in experiment I and II no biological relevant increase in revertant colonies was seen in
any of the five tester strains following treatment with 1,5-naphthalenediol neither in the
absence nor in the presence of S9-mix. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
under the experimental conditions used 1,5 -naphthalenediol was not genotoxic
(mutagenic) in the gene mutation tests in bacteria - Executive summary:
SCCS (2010) reported
1,5-Naphthalenediol was investigated for the induction of gene mutations in Salmonella typhimurium (Ames test) using TA98, TA100, TA102, TA1535 and TA1537 and concentrations up to 5000 µg/plate in the presence and in the absence of a metabolic activation system. Both in experiment I and II no biological relevant increase in revertant colonies was seen in any of thefore tester strains following treatment with 1,5-naphthalenediol neither in the absence nor in the presenceof S9-mix.
Thus, under the experimental conditions used 1,5 -naphthalenediol was not genotoxic (mutagenic) in the gene mutation tests in bacteria
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