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Diss Factsheets
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EC number: 201-487-4 | CAS number: 83-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only as secondary citation available: guideline study and GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Naphthalene-1,5-diol
- EC Number:
- 201-487-4
- EC Name:
- Naphthalene-1,5-diol
- Cas Number:
- 83-56-7
- Molecular formula:
- C10H8O2
- IUPAC Name:
- naphthalene-1,5-diol
- Test material form:
- other: solid
- Details on test material:
- content: 99.9 %
batch no. 820211/01
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- no data
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- Experiment I : 5, 25 and 50% in acetone /olive oil
Experiment II: 0.25, 1 and 2.5 % in acetone/olive oil - No. of animals per dose:
- 3 females per dose
- Details on study design:
- Experiment I:
Initially, 3 groups of animals were tested with 3 test substance concentrations, respectively.
Experiment II:
Based on the results, 3 additional groups were treated with 3 lower concentrations.
In each experiment, during the induction phase, the test item was applied over the dorsal ssurface of each ear (25 µl per ear) for 3 consecutive days (day1, 2, 3). On day 6 each animal was administered with radio-labeled thymidine (3HTdR) by intravenous injection. After 5 hours, the animals were euthanized and the draining lymph nodes were excised and pooled to prepare single cell suspension for each animal.
3HTdR incorporation was measured by scintillation counting. the proliferative response of lymph node cells was expressed as the ratio 3HTdRincorporation into lymph node cells of treated animals relatife to that recorded in control animals
Reference was made to separate experiments eith vehicle control animals and for reliability check with alpha-hexylcinnamaldehyde as positive control , respectively. - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Statistics:
- no data
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: see Remark
- Remarks:
- Experiment I: concentration [%] / Stimulation Index (SI) : 5 / 18.4; 25 / 16.7; 50 / 6.1 Experiment II: concentration [%] / Stimulation Index (SI): 0.25 / 1.4; 1 / 2.5; 2.5 / 2.8 Based on these data an EC value of 3.4 % was calculated
Applicant's summary and conclusion
- Executive summary:
SCCS (2010) describes the performance of a Local Lymph Node Assay (LLNA) according to OECD TG 429 and GLPand yielded positive result with a calculated EC3-value of 3.4 % . Based on the the potency categorisation given in ECHA Guidance Document R8 -10 (Version 2), 2010 it is concluded that 1,5-naphthalenediol is a moderate skin sensitizer.
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