Registration Dossier
Registration Dossier
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EC number: 449-360-4 | CAS number: 647828-16-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of the test material to Daphnia magna was assessed according to OECD TG 202 and in compliance with GLP. As the water solubility value of the test material was less than 0.202 mg/L, the maximum concentration employed in the study was 0.20 mg/L. A preliminary solution in Dimethylformamide was used to spike the test medium. Chemical analysis of the freshly prepared test media at 0 and 24 hours showed measured concentrations to range from 75% to 85% of nominal for the uncentrifuged samples, and from 52% to 57% of nominal for the centrifuged samples. Analysis of the 24-h old media at 24 and 48 hours showed measured concentrations to range from 63% to 70% of nominal for the uncentrifuged samples and from 43% to 47% of nominal for the centrifuged samples. The results are based on the mean measured concentrations of the centrifuged test media (bioavailable concentration) as a 'worst case' analysis of the data. No effects were observed on the mobility of the Daphnia. The 48h-EC50 was determined to be > 0.099 mg/L (measured). Based on the nominal test concentration, the 48-h EC50 was determined to be > 0.20 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 0.099 mg/L
Additional information
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