Registration Dossier
Registration Dossier
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EC number: 908-820-9 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from TSCA 8e section; no full report in hand but result has impact on hazardous properties and classification and labelling of test material
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test material
- Reference substance name:
- Reaction mass of (E)-1-chlorobut-2-ene and 3-chlorobut-1-ene
- EC Number:
- 908-820-9
- Molecular formula:
- not applicable
- IUPAC Name:
- Reaction mass of (E)-1-chlorobut-2-ene and 3-chlorobut-1-ene
- Details on test material:
- A mixture of approx. 50:50 1-chloro-2-butene and 3-chloro-1-butene were tested.
Constituent 1
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 16.3 mg/L air (analytical)
- Other findings:
- - Potential target organs: CNS
Any other information on results incl. tables
2/6 animals died in the 2990 ppm group, 3/6 in the 4410 ppm and 5/6 in the 6290 ppm group. (LC50 ca. 4410 ppm) Clinical signs: Impairment of startle response from 359 ppm. At 2990 and 4410 ppm abnormal gait, impaired mobility, changes in arousal, hunched posture, irregular respiration. Approximate LC50 in mg/l: 4410 ppm * 90.55/24.45 * 1000 = 16.3 mg/l
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- 2/6 animals died in the 2990 ppm group, 3/6 in the 4410 ppm and 5/6 in the 6290 ppm group. (LC50 ca. 4410 ppm)
Clinical signs: Impairment of startle response from 359 ppm. At 2990 and 4410 ppm abnormal gait, impaired mobility, changes in arousal, hunched posture, irregular respiration. Approximate LC50 in mg/l: 4410 ppm * 90.55/24.45 * 1000 = 16.3 mg/l
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