2-(N-methyl-p-toluidino)ethanol

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Test material

Test material information

Constituent 1

Reference substance name:

2-(N-methyl-p-toluidino)ethanol

EC Number:

220-638-5

EC Name:

2-(N-methyl-p-toluidino)ethanol

Cas Number:

2842-44-6

Molecular formula:

C10H15NO

IUPAC Name:

2-[methyl(4-methylphenyl)amino]ethan-1-ol

Test material form:

liquid: viscous

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

20 °C

Vapour pressure:

0.062 Pa

Vapour pressure 2

Key result

Temp.:

25 °C

Vapour pressure:

0.115 Pa

Any other information on results incl. tables

1      Results

1.1     Test Item

The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):

Table 10.1-a    Experimentally Determined Vapour Pressures

T	T	p	Stand. Dev. p	RSD p
°C	K	Pa	Pa	%
30.0	303.2	2.09E-01	3.66E-03	1.8%
45.0	318.2	1.12E+00	4.36E-02	3.9%
60.0	333.2	5.04E+00	3.17E-01	6.3%

In this table, E-0X represents multiplication with 10^-X.

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

 

For the test item N-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT), the following vapour pressures at 20°C and at 25°C were calculated from the regression equation:

Table 10.1-b    Results Test Item

Vapour pressure at 20°C:	6.25* 10^-02Pa
Vapour pressure at 25°C:	1.15* 10^-01Pa

 

The linear regression of log p vs. 1/T gave a correlation coefficient r of - 1.0000, showing good repeatability and precision. Therefore, the determination is considered as valid.

1.2     Positive Control

For Diethylphthalate the following vapour pressure was determined and compared with recommended value:

Table 10.2-a    Results Positive Control

Vapour pressure (positive control) at 30°C:	1.29*10^-1Pa
Criterion for the vapour pressure of the positive control at 30°C	0.44*10^-1- 2.44*10^-1Pa

The vapour pressure met the validity criteria. Therefore the study can be considered as valid.

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the test item N-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT) was determined at three different temperatures (30, 45 and 60°C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss).
Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good repeatability, giving relative standard devia-tions of less than 7 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid.

Executive summary:

The vapour pressure ofN-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT)was determinedaccording to OECD 104 resp.EU A.4 using the effusion method (weight loss).

 

Vapour pressure was examined atthree different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (p).

Table3‑a        Vapour Pressures (Effusion Method)

Experiment	T	Mean p	Stand. Dev. p	RSD p
No.	K	Pa	Pa	%
1	303.2	2.09E-01	3.66E-03	1.8%
2	318.2	1.12E+00	4.36E-02	3.9%
3	333.2	5.04E+00	3.17E-01	6.3%

In this table, E-0X represents multiplication with 10^-x.

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

The graph log (p) vs. 1/T shows a straight line with a correlation coefficient of - 1.0000.

 

For the test itemN-(2-Hydroxyethyl)-N-Methyl-p-Toluidine (MHPT), the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:          6.25* 10^-02Pa

Vapour pressure at 25 °C:          1.15* 10^-01Pa