Registration Dossier
Registration Dossier
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EC number: 221-218-4 | CAS number: 3033-29-2
Endpoint summary
Administrative data
Description of key information
By read-across to Dioctyltin oxide, Dioctyltin mercaptopropionate is considered to have no skin sensitising activity.
Skin Sensitisation: Read-across to structurally similar substance DOTO (Dioctyltin oxide)
DOTO induced no skin sensitisation in a mouse Local Lymph Node Assay according to guidelines OECD 429 and EU Method B.42.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin Sensitisation: Read-across to structurally similar substance DOTO (Dioctyltin oxide)
The skin sensitisation potential of DOTO was determined in accordance with the standardised guidelines OECD 429 and EU Method B.42 using the mouse Local Lymph Node Assay. DOTO was applied as a 5, 10 or 25 % w/w preparation in propylene glycol. The positive control was shown to have the capacity to cause skin sensitisation confirming the validity of the protocol used for this study. The isotope concentration induced by DOTO was less than three-fold at all test concentrations and therefore DOTO is considered to be unlikely to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
By read-across to Dioctyltin oxide, which did not induce skin sensitisation in a Local Lymph Node Assay according to OECD Guideline 429 and EU method B.42, Dioctyltin mercaptopropionate is considered to have no skin sensitising activity. Target substance and source substances share the identical organotin moiety, and the organotin moiety is generally recognized as the relevant toxophore of organotins. Mercaptopropionic acid, which is as mercaptopropionate the moiety of the target substance which is not covered by the source substance, is not classified for skin sensitising effects.
In accordance with the Regulation (EC) No. 1272/2008, Dioctyltin mercaptopropionate does not require classification as a skin sensitiser. Dioctyltin mercaptopropionate is not classified for respiratory sensitisation because of lack of data.
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