Registration Dossier
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EC number: 221-218-4 | CAS number: 3033-29-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
By read-across to Dioctyltin oxide, the EC50 of Dioctyltin mercaptopropionate to invertebrates is considered to be greater than the water solubility, corrected for molecular weight the 48 h EC50 was > 0.26 mg/L.
Read-across to structurally similar substance: DOTO (Dioctyltin oxide)
Under the conditions of an OECD 202 and EU method C.2 guideline study, the 48 h EC50 of DOTO to the invertetratae Daphnia magna was found to be greater than the water solubility of DOTO.
Key value for chemical safety assessment
Additional information
Read-across to structurally similar substance: DOTO (Dioctyltin oxide)
The acute toxicity of DOTO to the fresh-water crustacean Daphnia magna was determined in a semi-static test conducted in accordance with OECD 202 and EU method C.2 and in line with GLP. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Due to the insolubility of DOTO, the study was performed with a water soluble fraction as a limit test. Under the conditions of the test, the 48 h EC50 of DOTO was found to be greater than the water solubility of DOTO.
Based on read-across to Dioctyltin oxide, corrected for molecular weight the 48 h EC50 was > 0.26 mg/L.
Supporting information was available in the form of Rufli (1988). The study was performed according to the OECD guideline 202. However the observations performed during the study did not extend past the 24 hour period, with no explanation as to why the 48 hour observation was not performed. The study lacked details in the reporting in some areas and some deficiencies were present in the performance of the test, such as the test concentrations were not maintained throughout the entire test period. As such the study was assigned a reliability score of 2 in line with the principles of assigning data quality as outlined in Klimisch (1997). As the results of the study confirmed the lack of toxicity observed in the more reliable key study, the study was considered reliable with restrictions and suitable as supporting information to the key study. Under the conditions of the test, the EC50 of DOTO in Daphnia magna was determined to be greater than the water solubility of DOTO.
Based on read-across to Dioctyltin oxide, corrected for molecular weight the 24 h EC50 was > 3.83E-4 mg/L.
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