diethyl pyridine-2,4-dicarboxylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From June 06, 2010 to July 29, 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

13.5 g/L

Temp.:

20 °C

pH:

4

Results and Discussions

The saturation concentration of MEXORYL SBU at 22.5 °C was estimated by a simplified flask method in the preliminary test to be higher than 10mg/L. Therefore, the flask shaking test was performed.

 After a shaking time of 25.0 hours, 48.5 hours and 72.5 hours, respectively, at 30.0 °C, the samples were equilibrated for another 24.75 hours at 20.0 °C. Afterwards, the samples were centrifuged, filtered, diluted and analyzed by HPLC. The water solubility of MEXORYL SBU at 20.0 °C was determined to be 13.5 g/L. The measured results differ by less than 15%. Therefore, the study is considered to be valid.

 The r² fit of the calibration curve was 1.0000 (optimum). This reflects the linearity of the HPLC system within the calibration range of 1.188 µg/mL to 95.04 µg/mL of the test item.

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)During this study the water solubility of MEXORYL SBU was determined and found to be 13.5 g/L at 20.0 °C and a pH of 4.0 using the flask shaking method.

Executive summary:

During this study the water solubility of MEXORYL SBU was determined. Vessels containing water and test item were shaken for 25.0 hours, 48.5 hours and 72.5 hours, respectively, at 30.0 °C. Afterwards the samples were equilibrated for another 24.75 hours at 20.0 °C. After dilution with acetonitrile the concentrations in the aqueous solutions were determined by a HPLC method.

 

The water solubility of MEXORYL SBU was determined to be

 

13.5 g/L at 20.0 °C and a pH of 4.0

 

using the flask shaking method.

Description of key information

During this study the water solubility of MEXORYL SBU was determined. Vessels containing water and test item were shaken for 25.0 hours, 48.5 hours and 72.5 hours, respectively, at 30.0 °C. Afterwards the samples were equilibrated for another 24.75 hours at 20.0 °C. After dilution with acetonitrile the concentrations in the aqueous solutions were determined by a HPLC method.

The water solubility of MEXORYL SBU was determined to be 13.5 g/L at 20.0 °C and a pH of 4.0 using the flask shaking method.

Key value for chemical safety assessment

Water solubility:

13.5 g/L

at the temperature of:

20 °C