diethyl pyridine-2,4-dicarboxylate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From September 17, 2010 to July 26, 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Temp.:

25 °C

Vapour pressure:

0.022 Pa

Transition / decomposition:

no

The vapor pressure of MEXORYL SBU was determined at 20 °C, 30 °C and 40 °C. The vapor pressure of MEXORYL SBU at 25 °C was calculated by interpolation from the vapor pressure curve.

The tabulated values represent rounded results that were obtained by calculation using the exact raw data. The vapor pressure of MEXORYL SBU was determined at 20 °C, 30 °C and 40 °C. To ensure saturation control, three different flow rates were used at each temperature. It can be clearly seen that higher flow rates did not lead to lower vapor pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

 

The experimental results lead to the conclusion that the vapor pressure of the test item MEXORYL SBU is:

1.2 x 10^-2Pa at 20 °C

4.1 x 10^-2Pa at 30 °C

1.1 x 10^-1Pa at 40 °C

 

The vapor pressure at 25 °C was interpolated from the vapor pressure curve and was calculated to be 2.2 x 10^-2

 

The trapping efficiency of the test item MEXORYL SBU in the first cooling trap was very good. More than 98.3% of the test item was trapped in the first cooling trap.

The calibration data for test item-standards is given in Figure 4 and Table 5.The r² fit for the calibration data for test item-standards was 1.0000 (optimum 1.0000). This reflects the suitability of the HPLC-system within the calibration range of 0.585 µg/mL to 117.0 µg/mL of the test item. The good reproducibility and independency of the results from the flow rate led to the conclusion that the results of the vapor pressure determination of the test item MEXORYL SBU are reliable.

Experimental Parameters used for the Gas Saturation Method of MEXORYL SBU

Column	Temperature	Flow Rate	Collecting Time	Volume V1
No.	[°C]	[mLn/min]	[min]	[mLn]
1	20.2	41.40	1378	57049.20
2		53.25		73378.50
3		62.70		86400.60
1	30.1	41.60	4354	181126.40
2		51.60	4272	220435.20
3		62.77	4354	273300.58
1	39.8	41.10	1344	55238.40
2		52.60		70694.40
3		63.50		85344.00

 

 

Results of the Vapor Pressure Determination of MEXORYL SBU

Column No.	Temp.	Volume* V2	Amount of test item in trap 1	Amount of test item in trap 2**	Total amount of test item	Vapor pressure	Average vapor pressure
	[°C]	[mL]	[µg]	[µg]	[µg]	[Pa]	[Pa]
1	20.2	61268	67.939	<1.170	<69.109	1.2E-02	1.2E-02
2		78805	87.357	<1.170	<88.527	1.2E-02
3		92790	100.092	<1.170	<101.262	1.2E-02
1	30.1	201086	689.247	<1.170	<690.417	3.9E-02	4.1E-02
2		244726	907.047	<1.170	<908.217	4.2E-02
3		303417	1098.814	<1.170	<1099.984	4.1E-02
1	39.8	63287	660.977	<1.170	<662.147	1.2E-01	1.1E-01
2		80995	758.725	<1.170	<759.895	1.1E-01
3		97779	852.018	<1.170	<853.188	1.0E-01

 

 

Trapping Efficiency of MEXORYL SBU

Column	Testing Temperature	Amount of test item in 1^sttrap	Amount of test item in 2^ndtrap	Total amount of test item	Trapping efficiency 1^sttrap
No.	[°C]	[µg]	[µg]	[µg]	[%]
1		67.939	<1.170	<69.109	>98.31
2	20.20	87.357	<1.170	<88.527	>98.68
3		100.092	<1.170	<101.262	>98.84
1		689.247	<1.170	<690.417	>99.83
2	30.10	907.047	<1.170	<908.217	>99.87
3		1098.814	<1.170	<1099.984	>99.89
1		660.977	<1.170	<662.147	>99.82
2	39.80	758.725	<1.170	<759.895	>99.85
3		852.018	<1.170	<853.188	>99.86

*       Corrected volume at test temperature as calculated under “Volume correction”

**      No test item could be detected at the relevant retention time

Conclusions:

Calculation of the vapor pressure of MEXORYL SBU at 25 °C by interpolation based upon the simplified Clausius-Clapeyron equation resulted in a vapor pressure of 2.2 x 10-2 Pa at 25 °C.

Executive summary:

During this study, the vapor pressure of the test item MEXORYL SBU has been determined using the gas saturation method. The vapor pressure of MEXORYL SBU was measured at test temperatures of 20 °C, 30 °C and 40 °C and was determined to be 1.2 x 10^-2Pa at 20 °C, 4.1 x 10^-2Pa at 30 °C, 1.1 x 10^-1Pa at 40 °C. The vapor pressure of MEXORYL SBU at 25 °C was interpolated from the vapor pressure curve and was calculated to be 2.2 x 10^-2Pa at 25 °C.

Description of key information

During this study, the vapor pressure of the test item MEXORYL SBU has been determined using the gas saturation method. The vapor pressure of MEXORYL SBU was measured at test temperatures of 20 °C, 30 °C and 40 °C and was determined to be 1.2 x 10^-2Pa at 20 °C, 4.1 x 10^-2Pa at 30 °C, 1.1 x 10^-1Pa at 40 °C. The vapor pressure of MEXORYL SBU at 25 °C was interpolated from the vapor pressure curve and was calculated to be 2.2 x 10^-2Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:

0.022 Pa

at the temperature of:

25 °C