Registration Dossier
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EC number: 943-434-4 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Read-across from analogue substances Alcamizer 5 (EC 422-150-1) and Aluminium-magnesium-zinc-carbonate-hydroxide (EC 423-570-6):
ErC50 Algae freshwater (OECD 201 and GLP guidelines, no Mg and Al detected): > 18 mg test item/L (> water solubility and solubility limit in test medium)
ErC50 Algae freshwater (OECD 201 and GLP guidelines, based on Al measured concentrations): > 0.15 mg Al/L (i.e. > water solubility and solubility limit in test medium; this Al concentration corresponds with a loading rate of 100 mg/L)
NOErC (72h) Algae fresh water: 10 mg test item/L (> water solubility and solubility limit in test medium)
Overall conclusion: not toxic to freshwater algae up to the solubility limit in test medium
Key value for chemical safety assessment
Additional information
Read-across from analogue substances Aluminium-magnesium-zinc-carbonate-hydroxide (EC 423-570-6; P 93):
Several tests with P 93 were performed, both with freshwater and marine algae.
* Most recent study from 2007 (OECD 201, according to GLP principles): A filtered solution prepared at a loading rate of 100 mg Aluminium-magnesium-zinc-carbonate-hydroxide-hydrate per litre contained an average concentration of 0.15 mg aluminium per litre and a concentration of 0.12 mg zinc per litre. Algal cells (Pseudokirchneriella subcapitata) exposed to this solution for 48 hours were not affected (NOEC - 0.12 mg Zn/L, 0.15 mg Al/L). Therefore, the EC50 for both growth rate reduction and yield could not be reached.
* Studies from 1997: direct and indirect exposure of Selenastrum capricornutum to unfiltered test solutions (and dilutions thereof) of P 93. In the direct exposure test (turbid solutions), an ErC50 of 56 mg test item/L was derived (> water solubility and solubility limit in test medium). The NOEC was estimated at 10.7 mg test item/L. Also, it was found that algal growth recovered as exposure progressed. In the indirect exposure test the ErC50 was >100 mg test time/L (maximum loading rate).
* Study from 1997: Under the conditions of the test (saltwater), Aluminium-magnesium-zinc-carbonate-hydroxide-(hydrate) did not significantly inhibit cell growth or reduce growth rate of Skeletonema costatum at concentrations (loading rates) up to and including 180 mg/L (NOEC).
Read across from Alcamizer 5 (EC 422-150-1):
ErC50 Algae freshwater (OECD 201 and GLP guidelines, no Mg and Al detected): > 18 mg test item/L (> water solubility)
NOErC (72h) Algae fresh water: 10 mg test item/L (> water solubility)
Conclusion:
Based on reliable studies with analogue substances Alcamizer 5 and Aluminium-magnesium-zinc-carbonate-hydroxide (P 93), Aluminium magnesium carbonate hydroxide is considered to have an ErC50 > solubility limit in test medium.
Considering that Alcamizer P93 and Alcamizer 5 both contain additional elements and ions as compared to Aluminium magnesium carbonate hydroxide, which are potentially of concern to the environment, the environmental classification of the analogue substances will not be adopted.
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