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EC number: 639-566-4
CAS number: 165184-98-5
Skin irritation: irritating to the skin (Xi; R38) according to the Directive 67/548/EEC but not classified under the Regulation (EC) No. 1272/2008 (CLP)Eye irritation: Not classified.Respiratory irritation: No data.
A study was
identified as the key study (Brenda, 1993). This study was performed
according to the EU Method B.4 (Acute Toxicity: Dermal
Irritation/Corrosion) and in compliance with GLP. New Zealand White
rabbits were dermally exposed to undiluted Hexyl cinnamic aldehyde (HCA)
for 4 hours using a semi-occlusive patch. The mean individual scores
calculated within 3 scoring times (24, 48 and 72 hours) were 2/2/2 for
erythema and 1.33/1.67/1.67 for oedema. All the reactions were fully
reversible within 11 days.
test conditions HCA is classified as irritating to skin (Xi; R38)
according to the Directive 67/548/EEC but is not classified under the
Regulation (EC) No. 1272/2008 (CLP).
supporting studies show similar results.
A study was
identified as the key study (Brenda, 1994). This study was performed
according to the EU Method B.5 (Acute Toxicity: Eye Irritation /
Corrosion) and in compliance with the GLP.
0.1 mL of
undiluted HCA was instilled into the conjunctival sac of male New
Zealand White rabbits. Under the test conditions, HCA didn’t induce eye
irritation. A transient redness of the conjunctivae was observed in both
the 3 tested animals (scores 0.3/0.33/0.33) but was fully reversible
within 2 days.
test conditions, HCA is not irritating to eyes.
harmonized classification is available according to the Regulation (EC)
No 1272/2008 including ATP1.
erythema scores equal 2 in the 3 tested animals, Hexyl cinnamic aldehyde
is self-classified as irritating to skin (Xi; R38) according to the
criteria of the Annex VI to the Directive 67/548/EC. However HCA is not
classified under the Regulation (EC) No 1272/2008.
is not classified for eye irritation.
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