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EC number: 231-141-8 | CAS number: 7440-31-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 September 2009 to 14 October 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- Principles of method if other than guideline:
- Standard method - a group of five male and five female rats were exposed topically for 24 hours to a dose of 2000 mg/kg bw applied under a semi-occlusive dressing to intact dorsal skin. Clinical signs and bodyweight progression were monitored over the following two weeks and a full macroscopic examination completed at termination
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tin
- EC Number:
- 231-141-8
- EC Name:
- Tin
- Cas Number:
- 7440-31-5
- Molecular formula:
- Sn
- IUPAC Name:
- tin
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): tin metal powder (2-11 µm )
- Substance type: metal powder ground to ensure particle size was within the range of 2-11 µm
- Physical state: grey metallic powder
- Lot/batch No.: 090418
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK BIcester, Oxon, UK
- Age at study initiation: 8-12 weeks
- Weight at study initiation: at least 200 g (males - 225 to 247 g; females - 202 to 227 g on day 0)
- Fasting period before study: not applicable
- Housing: suspended polypropylene caging. Individually housed during treatment and group housed up to 5 rats per sex after dressing removal
- Diet: Available ad libitum. 2014 Teklan Global Rodent diet supplied by Harlan Teklad, Blackthorn Bicester, Oxon, UK.
- Water: Available ad libitum. Mains drinking water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19-25 °C
- Humidity: 30-70 % RH
- Air changes: 15 per hr
- Photoperiod: 12/12 (hrs dark / hrs light)
IN-LIFE DATES: From: 30 September 2009 To: 14 October 2009
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- arachis oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 8 x 10 cm area on the dorsum
- % coverage: 10 %
- Type of wrap if used: surgical gauze and adhesive bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): cotton wool moistened with arachis oil
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw adjusted for individual rat bodyweight on Day 0
- Concentration (if solution): not applicable
- Constant volume or concentration used: no
- For solids, paste formed: yes - powder moistened with arachis oil BP
VEHICLE
- Amount(s) applied (volume or weight with unit): Sufficient to moisten individual doses
- Concentration (if solution): not applicable
- Lot/batch no. (if required): not specified
- Purity: not specified (arachis oil BP) - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: The animals were observed for deaths or overt signs of toxicity 1/2, 1, 2 and 4 hours after dosing, and subsequently once daily for fourteen days.
- Frequency of observations and weighing:daily observations. Bodyweights recorded at day 0, 7 and 14. After the removal of the dressings and subsequently once daily the test sites were examined for evidence of primary irritation.
- Necropsy of survivors performed: At the end of the study the animals were killed by cervical dislocation. All animals were subjected to gross necropsy. This consisted of an external examination and opening of the abdominaal and thoracic cavities. The appearance of any macroscopic abnormalities was recorded. No tissues were retained. - Statistics:
- Data evaluations included the relationship, if any, between the exposure of the animal to the test material and the incidence and severity of all abnormalities including behavioural and clinical observations, gross lesions, bodyweight changes, mortality and any other toxicological effects.
Using the mortality data obtained, an estimate of the acute dermal median lethal dose (LD50) of the test amterial was made.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- There were no deaths.
- Clinical signs:
- other: No clinical signs indicative of reaction to treatment or of systemic toxicity were observed
- Gross pathology:
- No macroscopic abnormalities were evident during necropsy.
- Other findings:
- There were no dermal reactions at the treated sites.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU criteria
- Conclusions:
- The acute median lethal dermal dose to Wistar rats was greater than 2000 mg/kg bw.
- Executive summary:
A group of five male and five female Wistar rats was topically treated with 2000 mg/kg bw of tin metal powder (prepared to provide a particle size in the range 2 -11 µm) in a GLP compliant study conducted to current internationally accepted guidelines (OECD 402 and EU Method B.3). No evidence was found for dermal toxicity at the limit dose level.
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