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EC number: 231-141-8 | CAS number: 7440-31-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Brief summaries of experimental data, performed to non-standard methods.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 50 mg of tin dust was prepared in saline (to avoid aggregation), and injected into the trachea of rats through a laryngeal tube and blown into their lungs using 50 mg of silica as a control. Mice were injected with 5 mg of tin dust into a tail vein.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- basic toxicokinetics
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details reported
- Route of administration:
- other: intra-tracheal in rats, intra-venous in mice
- Vehicle:
- physiological saline
- Remarks:
- vehicles only reported in the intra-tracheal study
- Details on exposure:
- To avoid aggregation, dust was prepared in saline for the intra-tracheal exposure. 50 mg of tin dust in saline was injected through a laryngeal tube into the trachea of rats, and blown into their lung using 50 mg of silica as a control. The mice were injected with 5 mg into a tail vein.
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- Not applicable, dosed with dust from the occupational environment.
- Duration of treatment / exposure:
- Not applicable
- Frequency of treatment:
- Single exposure
- Post exposure period:
- 1 year (observations also reported at 4 months).
- Dose / conc.:
- 50 other: mg
- Remarks:
- intra-tracheal administration in rats
- Dose / conc.:
- 5 other: mg
- Remarks:
- intra-venous study in mice
- Control animals:
- not specified
- Positive control:
- Positive control rats dosed with silica in the intra-tracheal study
- Details on results:
- The animals reportedly withstood the procedure well. In the rats, four months after exposure, the rats showed an extreme density of the minute tin foci, and even in the close-up views the tiny foci appeared immensley desne on the X-rays. The histology showed than many areas had dust cells in them. The dust cells may line an alveolus, and the actual tin particles could easily be seen in the phagocytes, while sometimes the dust cell is in an alveoalr wall itself. Particles of tin were found in the sub-pleural lymphatics and in the mediastinal lymph glands.
In mice, after intra-venous injection, particles of dust were located inthe lungs, spleen and particularly in the liver, the dust was maily found near to a vein though sometimes noted lying amongst the liver cells. No cellular reactions were noted, and the mice were all healthy. - Conclusions:
- The experimental portion of this paper showed that in rats and mice exposed to dust from the sampling room in a tin smelter, there was no fibrous response of any kind up to a year.
Reference
Description of key information
Dust obtained from a tin smelting works was administered intra-tracheally in rats and via intra-venous injection in mice. In order to examine the fibrous response to occupational exposure in studying a non-fibrous pneumoconiosis. The experimental portion of this paper showed that in rats and mice exposed to dust from the sampling room in a tin smelter, there was no fibrous response of any kind up to a year.
Additional information
Robertson J (1960) was provided for information purposes only. The study, though not performed on tin metal, is relevant to general occupational exposure during the lifecycle of tin. As areas of reporting are lacking in detail, and the experimental portion was performed using non-standard routes of exposure, the study was assigned a reliability score of 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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