Registration Dossier
Registration Dossier
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EC number: 203-867-5 | CAS number: 111-41-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Does not significantly accumulate in organisms.
Key value for chemical safety assessment
Additional information
According to a study on the bioaccumulation potential of 2-(2-aminoethylamino)ethanol reporting a BCF ranging from 2.1 to < 3.7, the substance is not bioaccumulative (MITI 1992). This result is supported by a measured log Kow of -1.46 at a pH ranging from 10.6 to 11 (BASF AG, 1989).
The key study is additionally supported by a few QSAR calculations. The table below lists the applied (Q)SAR models, the estimated BCF values and basic information on the applicability domain (AD). Detailed information on the model’s results and the AD are given in the endpoint study records of IUCLID Chapter 5.3.1. The selected models comply with the OECD principles for (Q)SAR models.
Predicted BCF values from applied QSAR models sorted by BCF in ascending order:
(AD = Applicability Domain)
Model |
BCF |
In AD |
Restraints |
US EPA T.E.S.T. v4.1: Bioaccumulation: Consensus method |
0.84 |
yes |
- |
BCFBAF v3.01 (EPI Suite v4.11): Arnot & Gobas (2003), upper trophic, incl. biotransformation rates |
0.9 |
no |
- The maximum number of instances of biotransformation - As the substane appreciably ionizes at physiologically relevant pH, the estimation may additionally be less accurate. |
BCFBAF v3.01 (EPI Suite v4.11): Arnot & Gobas (2003), upper trophic, incl. biotransformation of zero |
0.9 |
no |
- The maximum number of instances of biotransformation -As the substance appreciably ionizes at physiologically relevant pH, the estimation may additionally be less accurate. |
BCF Read-Across v1.1.0 (VEGAv1.1.0) |
1.3 |
yes |
- |
CAESAR v2.1.14 (VEGA v1.1.0) |
3.0 |
yes |
- |
Meylan v1.0.2 (VEGA v1.0.8) |
3.0 |
no |
- The reliability of calculated logP value used by the model is not adequate. - The calculated LogP of this compound is outside the defined range [-1.37 to 11.26] |
BCFBAF v3.01 (EPI Suite v4.11): Meylanet al. (1997/1999) |
3.2 |
yes |
- |
Based on the experimental and the additionally calculated data, it can be concluded that significant accumulation in organisms is not to be expected.
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