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EC number: 204-435-9 | CAS number: 120-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The purity of the test substances was unknown. However, the study was well conducted and the results were quite detailed.
Data source
Reference
- Reference Type:
- publication
- Title:
- the metabolism of alicyclic ketones in the rabbit and rat.|- Bibliographic source
- Author:
- James SP, Waring RH
- Year:
- 1 971
- Bibliographic source:
- Xenobiotica, 1(6), 573-580
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Modified naphtharesorcinol method described by Bray et al. (1952), method of Folin, mass spectrometry and gas-liquid chromatography
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclopentanone
- EC Number:
- 204-435-9
- EC Name:
- Cyclopentanone
- Cas Number:
- 120-92-3
- Molecular formula:
- C5H8O
- IUPAC Name:
- cyclopentanone
- Details on test material:
- Cyclopentanone purchased from Koch-Light Ltd. No more data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: rats and rabbits
- Strain:
- other: WISTAR and NEW ZEALAND
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Species: rat and rabbit
- Strain: Wistar (rat) and White New Zealand (rabbit)
- Sex: female
- Source, Age at study initiation, Weight at study initiation, Fasting period before study, Housing, Individual metabolism cages, Diet, Water,
Acclimation period: data not available
ENVIRONMENTAL CONDITIONS (temperature, humidity , air changes, photoperiod: data not available
IN-LIFE DATES: data not available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- single exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Rats and rabbits received by gavage a dose of:
- cyclopentanone at 203 mg/kg bw and 193 mg/kg bw respectively,
- cyclohexanone at 245 mg/kg bw and 186 mg/kg bw respectively.
- No. of animals per sex per dose / concentration:
- no data available
- Control animals:
- no
- Details on study design:
- no data available
- Details on dosing and sampling:
- - Tissues and body fluids sampled: urine
- Time and frequency of sampling: data not available
Urine samples were collected and metabolites excreted in urine were analysed by:
- gas-liquid chromatography to determine sulphur-containing metabolites and 2-hydroxycycloalkylmercapturic acids.
- mass spectrometry to determine the methyl esters of the metabolites.
- the method of Folin to determine sulphate.
- the modified naphtharesorcinol method described by Bray et al. (1952) to determine glucuronic acid.
Liver extracted from undosed and dosed rats were prepared for the determination of total glutathione by the method of Martin & McIlwain (1959). - Statistics:
- no data available
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Sulphur containing metabolites were detected at 2.5% and 3% of the cyclopentanone administered dose, in rabbit and rat urine respectively:
- rabbits and rats excreted traces of the corresponding 2-hydroxycyclopentylmercapturic acids. Both cis and trans isomers of the
2-hydroxycyclopentylmercapturic acids were detected by gas-liquid chromatography.
- mass spectroscopic analysis suggested that further sulfur containing metabolite was the sulphate ester of 2-hydroxycyclopentylmercapturic acid.
It was excreted both in urine of rabbits (at 2% of the dose administered) and rats.
Glucuronic acid conjugate was the major metabolite in rabbits and found in urine at 47% of the dose administered.
Cyclopentanone gave a slight reduction in the level of total glutathione in the rat liver, presumably because glutathione was involved in the
metabolism of the cyclopentanone to the corresponding mercapturic acid.
After cyclohexanone administration, only cis 2-hydroxy- cyclohexylmercapturic acid was detected in rabbits and rats. Further sulphur-containing
metabolites excreted by both rabbits and rats were detected: it is also postulated that these metabolites were sulphate esters of hydroxymercapturic
acids.
In rabbits, the major metabolite of cyclohexanone was a glucuronide (66% of the dose).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
The major metabolite of cyclopentanone in rabbit after oral route (gavage) exposure is glucosiduronic acid (ca. 47%). Other metabolites were
excreted in rabbit urine such as ethereal sulphate (ca. 2%), sulphur-containing metabolite (ca. 2.5) and traces of 2-hydroxycycloalkylmercapturic
acids.
In rats, traces of the corresponding 2-hydroxycycloalkylmercapturic acids and small amounts of a second sulphur-containing metabolite are
excreted. - Executive summary:
In this study, rats and rabbits were treated (gavage, single exposure) with cyclopentanone (193 and 203 mg/kg bw) and cyclohexanone (186 and 245 mg/kg bw). Rabbits and rats dosed with cyclopentanone or cyclohexanone excrete traces of the corresponding 2 -hydroxycycloalkylmercapturic acids. In each case small amounts of a second sulphur-containing metabolite are excreted. In rabbits the major metabolite of cyclopentanone and cyclohexanone is glucosiduronic acid. In both species, the metabolism of cyclopentanone resembles that of cyclohexanone.
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