Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 262-996-5 | CAS number: 61788-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Good study, no GLP compliance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 67/548/CEE
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Castor oil, sulfated, sodium salt
- EC Number:
- 269-123-7
- EC Name:
- Castor oil, sulfated, sodium salt
- Cas Number:
- 68187-76-8
- IUPAC Name:
- Castor oil, sulfated, sodium salt
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material: Castor oil, sulfated, sodium salt
- Molecular formula: no data
- Molecular weight : no data
- Smiles notation: no data
- InChl: no data
- Substance type: no data
- Physical state:li quid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: breeding center Padre Antonio
- Weight at study initiation:2 - 3 kg
- Housing: stainless steel cage 1472 Tecniplast with autowashing (10 sec. every hour)
- Diet: full pellet, ad libitum.
- Water: municipal water filtered with Seitz filter, ad libitum.
- Acclimation period: 7 days
- Healt check: 24 hours before treatment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±1
- Humidity (%): 55±15
- Air changes (per hr):8
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 ml/animale - Duration of treatment / exposure:
- one injection
- Observation period (in vivo):
- 1, 24, 48, 72
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: according to DAIZE test
TOOL USED TO ASSESS SCORE: fluorescein, and UV lamp (365 nm)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 0.66
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- ca. 0.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 0.33
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- ca. 0.33
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- ca. 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: conjunctive congestion score
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- ca. 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: conjunctive congestion score
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 72
- Score:
- ca. 1.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: conjunctiva chemosis
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- ca. 0.66
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: conjunctiva chemosis
Any other information on results incl. tables
tissue | observation period | rabbit | Mean | |||||
1 | 2 | 3 | 4 | 5 | 6 | |||
Cornea | 1h | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 |
24h | 1 | 1 | 1 | 0 | 1 | 0 | 0.66 | |
48h | 1 | 1 | 1 | 0 | 1 | 0 | 0.66 | |
72h | 1 | 1 | 1 | 0 | 1 | 0 | 0.66 | |
7days | 1 | 1 | 1 | 0 | 1 | 0 | 0.66 | |
Iris | 1h | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 |
24h | 1 | 0 | 0 | 0 | 1 | 0 | 0.33 | |
48h | 1 | 0 | 0 | 0 | 1 | 0 | 0.33 | |
72h | 1 | 0 | 0 | 0 | 1 | 0 | 0.33 | |
7days | 1 | 0 | 0 | 0 | 1 | 0 | 0.33 | |
Conjunctiva | 1h | 2 | 2 | 2 | 2 | 2 | 2 | 2.00 |
24h | 3 | 3 | 3 | 2 | 2 | 2 | 2.50 | |
48h | 3 | 2 | 2 | 2 | 2 | 2 | 2.16 | |
72h | 2 | 2 | 2 | 2 | 2 | 2 | 2.00 | |
7days | 1 | 1 | 1 | 1 | 1 | 1 | 1.00 | |
chemosis | 1h | 2 | 2 | 2 | 2 | 2 | 2 | 2.00 |
24h | 3 | 2 | 2 | 3 | 3 | 3 | 2.83 | |
48h | 3 | 2 | 2 | 2 | 2 | 3 | 2.33 | |
72h | 2 | 2 | 1 | 1 | 1 | 2 | 1.50 | |
7days | 1 | 0 | 1 | 1 | 0 | 1 | 0.66 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on results castrol oil is considered irritant for rabbit eyes.
- Executive summary:
Castrol oil is tested on albino rabbit's eyes by DRAIZE test (67/548/ECC method). Based on results after 7 days of observation , castrol oil is considered irritant for rabbit eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.