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EC number: 201-067-0
CAS number: 77-90-7
are available concerning the toxicity of acetyl tributyl-citrate to
fish, aquatic invertebrates and algae: Short-term effects were
investigated with fresh- and salt water fish and with a freshwater
crustacean species in standard tests. Furthermore, a limit test on
chronic toxicity to daphnids is available.
assessing short-term effects on fish, reliable 96 h LC50 values are
available from 2 flow-through tests. The 96-hour LC50 for the saltwater
species Fundalus heteroclitus was 59 mg/L and for the fresh water
species Lepomis macrochirus the LC50 values ranged between 38 and
60 mg/L. Both test results were based on nominal concentrations. The
test concentrations were chemically analysed, however, the recovery of
the test substance was unsatisfactory in the short-term tests and
nominal concentrations were used for the evaluations.
lowest LC50 value obtained in the fish studies was considered most
relevant for the aquatic hazard assessment:
LC50 Lepomis machrochirus 38 mg/L.
assessing short-term effects on crustaceans, two reliable short-term
tests are available. Immobilisation of Daphnia magna was
studied in a static test according to OECD 202. Test solutions up to 1
mg/L (the maximum soluble concentration) were applied, ethanol was used
as vehicle. After 24 h no immobilisation was observed in all test
toxicity of tributyl acetylcitrate towards algae was investigated in a
study conducted with Desmodesmus subspicatus according to EU
Method C.3 (Algal Inhibition test; 2008) and OECD Guideline 201 (Alga,
Growth Inhibition Test; 2006). Based on the results of a screening test,
test substance concentrations of 10, 20, 40, 80, and 100 mg/L nominal
were used. Due to the poor water solubility of the test substance water
accommodated fractions were prepared and used in the tests. The
stability of the test substance was checked by IR measurements. Based on
the comparison of test substance concentrations/recoveries at time 0 and
after 72h it can be concluded that the test substance was stable during
the test duration (recovery around 80%). Based on this, the reported
effect concentrations refer to mean measured (arithm. mean)
concentrations of the aqueous phase. In respect to both, growth rate and
yield, the 72 h NOEC and LOEC values were determined to be 4.65 and 10.9
mg/L, respectively. The 72 h EC50 for growth rate was determined to be
74.4 mg/L. In respect to yield, the 72 h EC50 was determined to be 11.5
mg/L (95% C.I. for both parameters could not determined).
toxicity of tributyl acetylcitrate towards activated sludge was
investigated in a study conducted according to EU Method C.11
(Biodegradation: Activated Sludge Respiration Inhibition Test; 2008) and
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test;
1984). Based on the results of a screening test, the definitive test was
performed as a limit test using three parallels with the highest nominal
concentration of ca. 1000 mg/L. A fourth flask containing test substance
(1006 mg/L), tap water and synthetic sewage feed was used for testing
autoxidation of the test substance. At the concentration tested no
inhibitory effects were observed (3 h EC10>1000 mg/L nominal).
studies on long-term effects on aquatic organisms are available.
In a chronic test on invertebrates, the influence of ATBC on the
survival and reproduction rate of Daphnia magna was determined
during an exposure period of 21 days. The 21-day NOEC was determined to
be ≥ 1.11 mg test item/L for the reproduction rate and ≥ 1.11 mg test
item/L for the survival of the adult test animals, respectively. The
EC50 for the reproduction rate was > 1.11 mg test item/L.
of PNECaquatic organisms freshwater
data for species from three trophic levels, a study on chronic toxicity
to daphnia toxicity as well as a NOEC for algal growth are available for
acetyl tributyl citrate (ATBC). In this case an assessment factor of 50
has to be applied.
most sensitive endpoint was the 21d-NOEC from a limit test with Daphnia
magna of ≥ 1.11 mg test item/L.
freshwater= 1.11 mg ATBC/L / 50 = 22 µg ATBC/L
of PNECaquatic organisms marine
greater species diversity in the marine environment compared to
freshwater, including the presence of a number of taxa that occur only
in that environment, may mean that the distribution of sensitivities of
species is broader. Therefore, an assessment factor of 500 is applied to
the most sensitive NOEC.
marine= 1.11 mg ATBC/L / 500 = 2.2 µg ATBC/L
is a 3 h-EC10 of>1000 mg/L available, obtained from an Activated Sludge
Respiration test. Using an assessment factor of 10, the PNEC is
1000 mg ATBC/L / 10 = 100 mg ATBC/L
available data set does not include a single data on the effects of
acetyl tributyl citrate on sediment organisms. The PNEC may
provisionally be calculated using the equilibrium partitioning method
with the PNEC for aquatic organisms and the water/sediment partioning
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