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EC number: 425-200-9
CAS number: 188570-78-7
Table 1 Dermal
Rabbit no. & sex
E = Erythema
O = Oedema
60 minutes after removal of the dressing
of the stratum corneum (Characterised by dryness and sloughing)
A study was performed to assess the skin
irritation potential of Montaverdi to the rabbit. The method followed
was that described in:
EEC Methods for the determination of
toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B,
Method B.4. Acute toxicity (skin irritation) and OECD Guideline for
Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion".
Adopted: 17 July 1992. Three rabbits were each administered a single
dermal dose of 0. 5 ml of the test substance and observed for up to 14
days. A single semi-occlusive application of Montaverdi to intact rabbit
skin for four hours elicited persistent welldefined dermal irritation.
Reactions had resolved in one animal by Day 10 but slight erythema was
noted in the remaining two rabbits at study termination on Day 14. The
effects seen in 2 of the animals for the 14 day observation period were only
minimal in nature and therefore classification as a category 2 irritant is
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