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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC-Directive 92/69 B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: rat / Wistar Crl:(WI)BR

Administration / exposure

Vehicle:
other: 1% Aqueous carboxymethyl cellulose

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
832 mg/kg bw
Remarks on result:
other: Slope of the mortality curve: 24.6
Mortality:
Male: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 900 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 900 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
Signs of toxicity related to dose levels:
The deaths occurred between approx. 30 minutes and 24 hours
after dosing.

Clinical signs:

400 mg/kg: Lethargy, hunched posture, uncoordinated
movements, pale appearance, salivation, watery discharge
from the eyes.

900 mg/kg: Lethargy, tremors, ventro-lateral recumbency,
hunched posture, uncoordinated movements, pale appearance,
watery discharge from the eyes, dark coloured eyes.

2000 mg/kg: Lethargy, tremors, tonic spasms.


Symptoms had disappeared in the surviving animals between 2
hours and 6 days after dosing.
Gross pathology:
Effects on organs:
Body weight: no findings

Macroscopic:

Haemorrhages in the glandular stomach observed among animals
that died during the study. Haemorrhages in the thymus were
observed in one animals that died during the study.

No further findings.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU