Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
TRGS 900

Data source

Reference
Reference Type:
other: Technische Regeln für Gefahrstoffe (TRGS) 900
Title:
Unnamed
Year:
2001

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Technische Regeln für Gefahrstoffe TRGS 900
GLP compliance:
no
Test type:
other: human data
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: human

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
other: general dust limit (alveoli fraction)
Effect level:
6 mg/m³ air
Based on:
other: dust (alveoli fraction)
Remarks on result:
other: Short-term exposure was calculated as twice of the general dust limit (aveoli fraction) - 3 mg/m³

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The general dust limit is calculated for the short-term exposure, 6 mg/m³ alveoli fraction.
Executive summary:

Due to its non-toxic properties of crystallyne silica, no data on short-term exposure are available. Consequently, for calculation of the short-term exposure twice of the general dust limit of 3 mg/m³ (alveoli fraction) was used, as recommended by the Ausschuss für Gefahrstoffe.