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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
TRGS 900

Data source

Reference
Reference Type:
other: Technische Regeln für Gefahrstoffe (TRGS) 900
Title:
Unnamed
Year:
2001

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Technische Regeln für Gefahrstoffe TRGS 900
GLP compliance:
no
Test type:
other: human data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicon dioxide
EC Number:
231-545-4
EC Name:
Silicon dioxide
Cas Number:
7631-86-9
Molecular formula:
O2Si
IUPAC Name:
dioxosilane

Test animals

Species:
other: human

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
other: general dust limit (alveoli fraction)
Effect level:
6 mg/m³ air
Based on:
other: dust (alveoli fraction)
Remarks on result:
other: Short-term exposure was calculated as twice of the general dust limit (aveoli fraction) - 3 mg/m³

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The general dust limit is calculated for the short-term exposure, 6 mg/m³ alveoli fraction.
Executive summary:

Due to its non-toxic properties of crystallyne silica, no data on short-term exposure are available. Consequently, for calculation of the short-term exposure twice of the general dust limit of 3 mg/m³ (alveoli fraction) was used, as recommended by the Ausschuss für Gefahrstoffe.