Registration Dossier

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
HYPOTHESIS FOR THE ANALOGUE APPROACH
Target and source substances belong to the family of silicates. Silicates are known to be practically non-toxic as can be seen on the ECHA website for the source substances. Target and source substances only differ with respect to their morphology. They only differ on the microscopic level. However, this does not alter the substance properties of source substances and target substance at the macroscopic level. For further details please refer to the read across justification under IUCLID section 13.
Cross-reference
Reason / purpose:
read-across source
Reference
Endpoint:
skin sensitisation, other
Type of information:
not specified
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
according to
Guideline:
other: not specified
GLP compliance:
not specified
Type of study:
not specified
Key result
Remarks on result:
no indication of skin sensitisation

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Results and discussion

In vivo (non-LLNA)

Results
Key result
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met