Registration Dossier
Registration Dossier
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EC number: 906-265-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Data for the main components for skin irritation:
MEG: Not irritating at all
DEG: Very slight irritation
KAc (read across for sodium acetate): Not iritating at all
Data for the main components for eye irritation:
MEG: Negligible irritation produced
DEG: Slight irritation
KAc (read across for sodium acetate): Slight irritation, fully reversed within 48 hours.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Monoethylene glycol and the read across substance potassium acetate do not produce any signs of skin irritation when tested using in vivo assays. Pure diethylene glycol produces slight irritation in similar studies but at levels that are insufficient to require classification. When tested at 10% it produces no irritation response.
Monoethylene glycol produces negligible irritation in an in vivo study. Diethylene glycol produces slight irritation in in vivo studys but this is quickly reversed. Potassium acetate, a read across substance for sodium acetate, produces slight chemosis and conjunctival effects but these full reverse within 24 -48 hours.
Justification for classification or non-classification
Two of the main components of this multi-constituent substance produce no skin irritation at all and one only shows very slight and transient skin irritation properties. The criteria for classification for none of the main components are met and therefore the criteria for classification for skin irritation are not met based on the intrinsic hazards of the main components. It should be borne in mind that this substance can contain alkaline impurities that can lead to classification based on the pH of the final composition.
One of the main components of this multi-constituent substance shows negligible eye irritation. The other two components produce slight irritation that is quickly reversed. The criteria for classification for none of the main components are met and therefore the criteria for classification for eye irritation are not met based on the intrinsic hazards of the main components. It should be borne in mind that this substance can contain alkaline impurities that can lead to classification based on the pH of the final composition.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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