Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
The justification of read across is described in the attached justification

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse

Results and discussion

Main ADME results
Type:
metabolism
Results:
Readily cleaved

Applicant's summary and conclusion

Conclusions:
Based on this read across approach on the APG-C8, the APP-C5 is readily cleaved