Registration Dossier
Registration Dossier
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EC number: 700-330-1 | CAS number: 433733-92-7
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 2,2’-anhydro-1-(b-L-arabinofuranosyl)-5-methyluracil
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- 2,2’-anhydro-1-(b-L-arabinofuranosyl)-5-methyluracil
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The substance has low logKow value -1.97 and is not of greater concern because it has low potential to bio-concentrate in living organisms. Bioconcentration Factor (BCF) is 0.053 - 0.066 and it is an indicator that this substance does not have the tendency to accumulate in the living organism.
It is not readily degradable.
Hydrolysis, the half-life time of the test substance:
at pH = 4 and 7 and Temperature 25 °C is > 1 year;
at pH=9 and Temperature: 20 °C is 91 days,
Temperature: 25 °C is 43 days
Temperature 60°C is 12 hours.
The substance is solely used in pharmaceutical industry as intermediate.
The substance is 76% converted in the process of synthesizing active pharmaceutical ingredient. Waste stream goes to Waste Water Treatment Plant. Sludge is sent for off-site incineration. No exposure of the environment is expected.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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