Registration Dossier
Registration Dossier
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EC number: 614-648-2 | CAS number: 68606-83-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Acute Dermal irritation experiment
- GLP compliance:
- yes
Test material
- Reference substance name:
- Essential oil of Cananga odorata ext. obtained from the flowers of Cananga odorata macrophylla by steam distillation
- Cas Number:
- 68606-83-7
- IUPAC Name:
- Essential oil of Cananga odorata ext. obtained from the flowers of Cananga odorata macrophylla by steam distillation
1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Remarks:
- 1-2 (3/6)
- Basis:
- animal: Rabbit
- Time point:
- 24/48/72 h
- Remarks on result:
- probability of weak irritation
- Remarks:
- No time points provided in the Report. Only a summary of edema score.
- Irritation parameter:
- erythema score
- Remarks:
- 2-4 (6/5)
- Basis:
- animal: Rabbit
- Time point:
- 24/48/72 h
- Score:
- > 2 - < 4
- Remarks on result:
- probability of weak irritation
- Remarks:
- No time point provided in the report. Only Erythema score provided.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Remarks:
- Mild irritation reported in Toxicological study.
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