Registration Dossier
Registration Dossier
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EC number: 614-648-2 | CAS number: 68606-83-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Acute Dermal Toxicity experiment on rabbits
- GLP compliance:
- yes
Test material
- Reference substance name:
- Essential oil of Cananga odorata ext. obtained from the flowers of Cananga odorata macrophylla by steam distillation
- Cas Number:
- 68606-83-7
- IUPAC Name:
- Essential oil of Cananga odorata ext. obtained from the flowers of Cananga odorata macrophylla by steam distillation
1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Based on:
- test mat.
- Mortality:
- 0/6
- Other findings:
- Mild irritation.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Oral Acute toxicity shown in Rats to be >5 g/kg bodyweight, so can be classified in category 5 for GHS criteria.
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