Sodium O-ethyl dithiocarbonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Sodium ethyl xanthate: Acute Oral, Eye and Dermal Toxicity Report

Author:

Hazleton Laboratories

Year:

1951

Bibliographic source:

Acute Oral, Eye and Dermal Toxicity Report”, Virginia, USA, 1951.

Reference 2

Reference Type:

review article or handbook

Title:

Oral toxicity of xanthates

Author:

Kirk-Othmer Encyclopaedia of Chemical Technology

Year:

1984

Bibliographic source:

Vol 24, 2nd ed, pp 645-661, John Wiley & Sons, 1984.

Reference 3

Reference Type:

review article or handbook

Title:

Priority existing chemical Report No. 5

Author:

Dep. of Health and Ageing, Australian Government

Year:

1995

Bibliographic source:

National Industrial Chemicals Notification and Assessment Scheme

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

The study was carried out in 1951 and complies generally with current test protocols such as the Organisation for Economic Cooperation and Development (OECD) guidelines for testing of chemicals No. 401. This study predates the requirements for good laboratory practice, however the study was considered adequate for this assessment. A 10% aqueous solution of sodium ethyl xanthate was administered orally by gavage. The pH of the solution was approximately 10.5 to 11. The animals were observed for signs of gross toxicological effects for seven days.

GLP compliance:

no

Test type:

other: LD50

Limit test:

no

Test material

Test material information

1

Reference substance name:

Sodium O-ethyl dithiocarbonate

EC Number:

205-440-9

EC Name:

Sodium O-ethyl dithiocarbonate

Cas Number:

140-90-9

Molecular formula:

C3H6OS2.Na

IUPAC Name:

sodium (ethoxymethanethioyl)sulfanide

Test material form:

solid: bulk

Details on test material:

SEX /sodium O-ethyl dithiocarbonate is produced by the reaction of an ethyl alcohol with sodium hydroxide to form alcoholate and subsequently adding carbon disulfide to form SEX/ sodium O-ethyl dithiocarbonate.
SEX /sodium O-ethyl dithiocarbonate contains Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) which are an integral part of the substance.
Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) are both reagents used in the manufacture of SEX /sodium O-ethyl dithiocarbonate. Therefore, Ethanol/ethyl alcohol (CAS number 64-17-5) and sodium hydroxide (CAS number 1310-73-2) need to be considered in the assessment of SEX /sodium O-ethyl dithiocarbonate.


CAS name: ethyl alcohol
EC / List name: Ethanol
IUPAC name: ethanol
EC / List no.: 200-578-6
CAS no.: 64-17-5

CAS name: sodium hydroxide
EC / List name: Sodium hydroxide
IUPAC name: sodium hydroxide
EC / List no.: 215-185-5
CAS no.: 1310-73-2

Test animals

Species:

mouse

Strain:

other: albino mice

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

500,600,750,900,1000,1500,2000,5000 mg

No. of animals per sex per dose:

93 male

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

730 mg/kg bw

Based on:

test mat.

Mortality:

The majority of deaths occurred on the first day and the animals that survived appeared normal within two days. The study does not indicate how many animals developed the symptoms, at what doses and the day of development of the symptoms.

Clinical signs:

other: Depression followed by hyperexcitability, tremors, paralysis, exophthalmia and clonic followed by tonic convulsions. Pinkness of feet and nose, preening and salivation.

Gross pathology:

Consolidated lungs, pale granular livers, unusually small spleens and atonic
intestines. Surviving animals showed no abnormalities.

Applicant's summary and conclusion

Interpretation of results:

other: sligthly toxic

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The LD50 value of 730 mg/kg was determined in a reliable study. This show that 10% aqueous solution of sodium ethyl xanthate is of a Slightly order of acute oral toxicity .
Based on the data provided in this review, SEX shall be classified for acute oral toxicity.

Executive summary:

The results of this study indicate that a 10% aqueous solution of sodium ethyl xanthate has an oral LD50 of 730 mg/kg in male mice. The target organs for oral toxicity of sodium ethyl xanthate were the central nervous system, liver and spleen.