Registration Dossier
Registration Dossier
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EC number: 205-440-9 | CAS number: 140-90-9
Toxicity to other above-ground organisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to other above-ground organisms
- Type of information:
- other: published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-3 (Wild Mammal Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- mouse
- Details on test organisms:
- TEST ORGANISMS:
Mus musculus (House Mouse). The organism(s) (age: 5 wk and organism characteristics of: SPF, DDY STRAIN) - Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 24 h
- Test temperature:
- 10-20 0C
Temperature was continuously recorded - Photoperiod and lighting:
- They were held at a photoperiod of 14:10 light:dark.
- Details on test conditions:
- The organism(s) -Mus musculus (House Mouse). The organism(s) (age: 5 wk and organism characteristics of: SPF, DDY STRAIN) were exposed for a duration of 24 hour(s) to a(n) 1 dosed x time(s) per study period application of Carbon disulfide (CAS # 75150) in Olive oil, Olive oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion.
- Nominal and measured concentrations:
- DOSES/500/1000/1500/2000 mg/kg//
- Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 500 mg/kg bw
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth
- Remarks on result:
- other: Weight gain
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 150 mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- TheNOELs can be converted to NOECs with the following two formulae: NOECmouse=NOELmouse.CONVmouse Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)
- Basis for effect:
- growth
- Remarks on result:
- other: Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi) NOECmouse=500 x 8.3=4150 mg/kg/diet
- Duration:
- 24 h
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 947 mg/kg bw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- Sodium ethyl xanthate
- Basis for effect:
- growth
- Remarks on result:
- other: On a molecular weight scaled basis, the NOEL would be 947 mg/kg bw. (500x 144.19) /76.13 =947 mg/kg bw
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7 860.1 mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- Sodium ethyl xanthate
- Basis for effect:
- growth
- Remarks on result:
- other: Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi) NOECmouse=947 x 8.3=7860.1 mg/kg/diet
- Details on results:
- For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECmouse=NOELmouse.CONVmouse
Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECmouse=500x 8.3=4150 mg/kg/diet - Validity criteria fulfilled:
- yes
- Conclusions:
- For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECmouse=NOELmouse.CONVmouse
Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECmouse=500x 8.3=4150 mg/kg/diet - Endpoint:
- toxicity to other above-ground organisms
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- SEX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SEX.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 71-3 (Wild Mammal Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- rat
- Details on test organisms:
- TEST ORGANISMS:
Rattus norvegicus (Norway Rat). The adult(s) (age: 60-90 d and organism characteristics of: LONG-EVANS) - Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 30 d
- Test temperature:
- 10-20 0C
Temperature was continuously recorded - Photoperiod and lighting:
- They were held at a photoperiod of 14:10 light:dark.
- Details on test conditions:
- 30 Daily for X days application of Carbon disulfide (CAS # 75150) in Corn oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions
- Nominal and measured concentrations:
- /DOSES/200 mg/kg//
- Reference substance (positive control):
- no
- Duration:
- 30 d
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 200 mg/kg bw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 000 mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- TheNOELs can be converted to NOECs with the following two formulae: NOECrat=NOELrat.CONVrat Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
- Basis for effect:
- growth
- Remarks on result:
- other: NOECrat=200 x 20=4000 mg/kg/diet Conversion factors from NOEL to NOEC for mammalian species Rattus norvegus >6 weeks is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
- Details on results:
- The NOEL for the Rattus norvegicus was 200 mg/kg bw for growth.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=200 x 20=4000 mg/kg/diet - Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEL for the Rattus norvegicus was 200 mg/kg bw for growth.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=200 x 20=4000 mg/kg/diet - Executive summary:
The NOEL for the Rattus norvegicus was 200 mg/kg bw for growth.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
The NOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=200 x 20=4000 mg/kg/diet
- Endpoint:
- toxicity to other above-ground organisms
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Referenceopen allclose all
A study of NC-NC Not Coded duration using no substrate media was conducted in a LAB site location with Not Coded obtained Mus musculus (House Mouse). The organism(s) (age: 5 wk and organism characteristics of: SPF, DDY STRAIN) were exposed for a duration of 24 hour(s) to a(n) 1 dosed x time(s) per study period application of Carbon disulfide (CAS # 75150) in Olive oil, Olive oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. (Reference 98738, Masuda,Y., M. Yasoshima, and N. Nakayama, 1986, Test Number 446233).
A study of NC-NC Not Coded duration using not reported media was conducted in a LAB site location with Not Coded obtained Rattus norvegicus (Norway Rat). The adult(s) (age: 60-90 d and organism characteristics of: LONG-EVANS) were exposed for a duration of 30 day(s) to a(n) 30 Daily for X days application of Carbon disulfide (CAS # 75150) in Corn oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result ofunmeasured analysis of chemical solutions and are based on the NR ion. (Reference 97752, Herr,D.W., W.K. Boyes, and R.S. Dyer, 1992, Test Number 444859).
Description of key information
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=200 x 20=4000 mg/kg/diet
Key value for chemical safety assessment
- Short-term EC50 or LC50 for mammals:
- 20 750 mg/kg food
- Long-term EC10, LC10 or NOEC for mammals:
- 4 000 mg/kg food
Additional information
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=200x 20=4000 mg/kg/diet
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