Pregna-1,4-diene-3,20-dione, 9-bromo-6-fluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (6.alpha.,11.beta.,16.alpha.)-

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08 July 2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.3 (Relative Density)

GLP compliance:

no

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

pycnometer method

Type:

relative density

Density:

1.383 other: dimensionless

Temp.:

20 °C

Remarks on result:

other: mean value of 2 determinations

Literature data (CRC Handbook of Chemistry and Physics 75th Edition)

d (20, w) (density of water at 20 °C) = 0.9982 g/mL

d (4, w) (density of water at 4 °C) = 0.99997 g/mL

d (20, a) (density of air at 20 °C) = 0.0012 g/mL

 

Validity criteria for the measurement of the density:

Target condition according to guideline:	Actual condition according to the study:	Validity criteria met:
The tests have to be run at 20 °C.	The tests were performed at 20°C.	Yes
At least two measurements have to be performed.	Two values were measured.	Yes
The relative density, D^204, of solids or liquids is the ratio between the mass of a volume of substance to be examined, determined at 20 °C, and the mass of the same volume of water, determined at 4 °C.  The relative density, D^204, shall be reported as defined, along with the physical state of the measured substance.	The values of the relative densities are stated without further detail to the method or calculation used. The phsyical state of the measured substance is not stated.	No. Nevertheless, although there are few details about the method stated in the study report, the relative density was determined according to guideline 92/69/EWG nad DIN 51757. Thus, the detailed specifications stated in these guidelines may be considered as being fulfilled.

Conclusions:

The density at 20 ºC was 1.383 g/cm3 and the relative density was 1.383.

Executive summary:

According to the OECD Guideline 109 (Density of Liquids and Solids) corresponding to A.3., Council Regulations EC No 440/2008 the solid sample was accurately weighed into a 20 mL pycnometer and by displacement of the solvent (n-heptan), its equivalent volume was determined. Finally, the density of the sample was calculated. The density at 20 ºC was 1.383 g/cm³and the relative density was 1.383.

Description of key information

The density at 20 ºC was 1.383 g/cm³ and the relative density was 1.383.

 

Key value for chemical safety assessment

Relative density at 20C:

1.383