Registration Dossier

Diss Factsheets

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 November 2016 to 17 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7370 (Dissociation constants in water)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
- Batch nĀ°: I16CB1581
- Analytical purity: 98.61 %
- Expiration date: 2019-04-04
- Storage condition: at room temperature
Dissociating properties:
no
Remarks:
The test item does not contain ionisable groups. No pKa values could be calculated.

The test item does not contain ionisable groups. No pKa values could be calculated

Conclusions:
JNJ-39453349-AAA (T003066) has no pKa values for acidic and basic groups in the logarithm range of 1 ā€“ 14.

Description of key information

The calculation method was applied in a GLP study (K1, Reingruber, 2017) as a preliminary test to determine the dissociation constant. Since the test item does not contain ionisable groups, no pKa could be calculated.

Key value for chemical safety assessment

Additional information