Registration Dossier
Registration Dossier
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EC number: 253-379-1 | CAS number: 37172-53-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl 2-hexyl-3-oxocyclopentanecarboxylate
- EC Number:
- 253-379-1
- EC Name:
- Methyl 2-hexyl-3-oxocyclopentanecarboxylate
- Cas Number:
- 37172-53-5
- Molecular formula:
- C13H22O3
- IUPAC Name:
- methyl 2-hexyl-3-oxocyclopentane-1-carboxylate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Description: Clear liquid
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 - 300g
- Fasting period before study: 18 hours
- Housing: 5/cage in wire mesh cages in a temperature controlled room
- Diet: Fresh Purina Rat Chow, ad libitum
- Water: Tap water, ad libitum
- Acclimation period: at least one week
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed: mortality and signs of toxicity at 3-4 hours after dosing and daily for 14 days. All rats were examined for gross pathology.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- discriminating dose
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: Lethargy was observed in 2 animals on day 0. Chromorhinorrhea was noted in 1 animal on day 9.
- Gross pathology:
- One animal had a dark liver and a pale kidney. One animal had red and yellow areas on intestines and a dark kidney.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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