Registration Dossier
Registration Dossier
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EC number: 253-379-1 | CAS number: 37172-53-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is found to be readily biodegradable and the applied test concentrations are in the range of concentrations that can be expected in the influent of a sewage treatment plant
Reference
Description of key information
Key value for chemical safety assessment
Additional information
In a biodegadability study (see relevant chapter in CSR/IUCLID), the biodegradability of the test substance was determined by a modified method according to OECD Guideline 301B and EU method C.4 -C, using a modified trapping system. In this study, the toxicity of the test substance was determined. The percentage degradation of sodium acetate (68 mg/L) and the test substance (29.0 mg/L) combined in the toxicity control was calculated on the basis of the sum of the theoretical CO2-production of both substances. The CO2-production was higher in the toxicity control than in the activity control (see table below). A net CO2 production of 60.4 mg CO2 could be attributed to the degradation of the test substance after 28 days. This corresponded to the mean value in the biodegradation test itself (53.7 mg). This means that the test substance was not toxic to the inoculum and was extensively degraded in the presence of acetate.
Results of the inoculum activity and inhibition control test with the test substance. The results are expressed as mg CO2 (cumulative) and as percentage biodegradation, based on the ThCO2 of acetate, or the ThCO2 of the sum of both substances. The results are the mean values.
Days |
Inoculum activity control |
Toxicity control |
||
mg CO2 |
%ThCO2 |
mg CO2 |
%ThCO2 |
|
7 |
40.5 |
55.6 |
47.4 |
32.4 |
14 |
52.4 |
72.0 |
84.1 |
57.5 |
14+ (1) |
59.9 |
82.3 |
- |
- |
21 |
57.4 |
78.9 |
106.3 |
72.7 |
28 |
60.2 |
82.8 |
117.0 |
80.1 |
28+ (1) |
63.2 |
86.9 |
123.6 |
84.6 |
(1) Including the CO2 in the medium released by acidification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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