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EC number: 405-520-5 | CAS number: 95235-30-6 D-8; DD-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-07-04 to 1988-12-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.36
- Temp.:
- 25 °C
- pH:
- 5
- Details on results:
- Calculation of Partition Coefficient:
From the HPLC analysis data, the Pow of D-8 was calculated as follows:
Oow = Co/Cw
Co or Cw : Cs x Au x Vs x F/As x Vu
where:
Co : Concentration in o-octanol phase (ppm)
Cw : Concentration in water phase (ppm)
Cs : Concentration of standard solution (mg/L)
Au : Mean of integral peak area of sample
Vs : Injected volume of standard solution (µL)
As : Mean of integral peak area of standard
Vu : Injected volume of sample solution
F : Concentration/dilution factor - Conclusions:
- The n-octanol/water partition coefficient of D-8 was determined by the flask shake method according to OECD guideline 107. The log Pow for D-8 was 3.36 ± 0.067 at 25 °C.
- Executive summary:
The n-octanol/water partition coefficient of D-8 was determined by the flask shake method according to OECD guideline 107. In a glass bottle, n-octanol saturated with water and water saturated with n-octanol were mixed at ratios of 50:50, 50:25 and 33:66 mL. About 30 mg of D-8 was added into each bottle. They were tightly capped and vibrated in an ultrasonic bath for 10 min. After vibration, they were shaken with 120 - 180 frequencies/min by a mechanical shaker for 40 min at 23 -25 °C. The mixture in the bottle was transferred into a centrifugal tube and centrifugated for 20 min by 12,000 rpm at 25 °C. After centrifugation 1 mL of n-octanol solution was gently pipetted from the upper layer of the tube into a 100 mL volumetric flask and diluted to the mark with acetonitrile. The aqueous solution was also gently collected from the center of the water layer by using a stomach tube equipped with a syringe.
The content of D-8 was determined with HPLC by injection of 10 µL of octanol and 20 µL of water layers. The log Pow for D-8 was determined to be 3.36 ± 0.067 at 25 °C.
Reference
Results:
The saturation time of 40 min was sufficient judged from a preliminary test. The results are summerize in the table.
The log Pow was 3.36 ± 0.067 and independent upon the ratio of volumes of n-octanol and water.
Description of key information
The log Pow for D-8 was 3.36 ± 0.067 at 25 °C, according to OECD Guideline 107.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.36
- at the temperature of:
- 25 °C
Additional information
The n-octanol/water partition coefficient of D-8 was determined by the flask shake method according to OECD Guideline 107. The log Pow for D-8 was 3.36 ± 0.067 at 25 °C.
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