Naphthenic acids, zinc salts

Repeated dose toxicity: dermal

Administrative data

Endpoint:

short-term repeated dose toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

a short-term toxicity study does not need to be conducted because a reliable sub-chronic (90 days) or chronic toxicity study is available, conducted with an appropriate species, dosage, solvent and route of administration

Justification for type of information:

Zinc naphthenate is exclusively manufactured in situ in base oil and not in isolated form, so the potential for dermal contact with the isolated substance is low. Also, the use of the grease forms is expected to significantly lower the rate of adsorption through the skin, so exposure to humans via the dermal route will be unlikely to occur. The use of zinc naphthenate as grease thickeners under industrial exposure considerations precludes the relevance of the dermal route for repeated dose toxicity testing. On the assumption that the test substances will be prepared specifically for purposes for registration rather than being representative of material ‘placed on the market’, the conduct of a subacute toxicity study by the dermal route of exposure is not considered relevant for the substance.

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified