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EC number: 234-409-2 | CAS number: 12001-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Water Solubility. July 27, 1995.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Water Solubility. March 04, 2016.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- Water Solubility: Column Elution Method; Shake Flask Method. March 1998.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Batch: A036/99 (Supplier batch number: SCC-1709-0300)
- Expiration date: 31 August 2018
- Storage condition of test material: Room temperature, protected from light - Water solubility:
- < 10 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 10 mg/L
- Incubation duration:
- 48 h
- Temp.:
- 25 °C
- pH:
- 7
- Details on results:
- - Conclusion: The flask method was applied for the determination of the water solubility of Naphthenic acids, zinc salts. Because of the observed spread, no mean value and therefore no maximum difference could be calculated. It is not expected that more accurate results can be obtained.
- pH: The pH of the aqueous samples was between 6.4 and 7.1.
- Analytical results: the analytical method was validated for the analysis of Naphthenic acids, zinc salts in water for the following parameters: Specificity; Calibration curve; Accuracy and Repeatability; Limit of quantification; Stability analytical system and end solutions. Samples in water have to be analysed freshly. - Conclusions:
- The water solubility of naphthenic acids, zinc salts was 31.4-56.3 mg/L at a loading rate of 100 mg/L and 134-198 mg/L at a loading rate of 1000 mg/L. Because of the observed spread, no mean value and therefore no maximum difference could be calculated. It is not expected that more accurate results can be obtained.
- Executive summary:
Charles River (2018) is a GLP-compliant study following OECD guideline 105 and is considered reliable without restrictions (Klimisch 1). The flask method was applied for the determination of the water solubility of Naphthenic acids, zinc salts. Because of the observed spread, no mean value and therefore no maximum difference could be calculated. It is not expected that more accurate results can be obtained.
Reference
Preliminary test: Water solubility of the test item after stirring for 48 hours
Loading rate [mg test item/L] |
Concentration dissolved Zn analyzed |
Equivalent concentration test item1 [mg test item/L] |
pH |
10 |
1.06 |
7.42 |
6.7 |
100 |
8.89 |
62.2 |
6.4 |
1000 |
32.7 |
229 |
6.2 |
10000 |
57.8 |
404 |
6.1 |
1 Content Zn in test item: 14.3%.
Preliminary test: Water solubility of the test item after
stirring for 49 hours
Loading rate [mg test item/L] |
Analyzed TOC concentration |
Analyzed TOC concentration |
pH |
blank |
0.129 |
n.a. |
|
10 |
3.89 |
3.76 |
6.7 |
100 |
28.7 |
28.5 |
6.5 |
1000 |
134 |
134 |
6.2 |
10000 |
289 |
289 |
6.1 |
Main study - water solubility of the test item at a loading rate of 100 mg/L
Stirring time |
Concentration dissolved Zn analyzed [mg Zn/L] |
Equivalent concentration test item1 [mg test item/L] |
pH |
24 |
6.35 |
44.4 |
7.1 |
48 |
8.05 |
56.3 |
6.8 |
72 |
4.48 |
31.4 |
7.0 |
1 Content Zn in test item: 14.3%.
Main study - water solubility of the test item at a loading rate of 1000 mg/L
Stirring time |
Concentration dissolved Zn analyzed [mg Zn/L] |
Equivalent concentration test item1 [mg test item/L] |
pH |
24 |
28.3 |
198 |
6.4 |
48 |
22.6 |
158 |
6.4 |
72 |
19.1 |
134 |
6.4 |
1 Content Zn in test item: 14.3%.
Main study - water solubility of the test item at a loading
rate of 100 mg/L
Stirring time |
Analyzed TOC concentration1 |
pH |
24 |
15.2 |
7.0 |
48 |
28.6 |
6.8 |
72 |
21.4 |
7.1 |
1 Corrected for response in the blank.
Main study - water solubility of the test item at a loading
rate of 1000 mg/L
Stirring time |
Analyzed TOC concentration1 |
pH |
24 |
69.6 |
7.0 |
48 |
82.9 |
6.8 |
72 |
103 |
7.1 |
1 Corrected for response in the blank.
Water solubility results
Loading rate |
Stirring time |
Equivalent test item concentration1 [mg test item/L] |
Analyzed TOC |
100 |
24 |
44.4 |
15.2 |
|
48 |
56.3 |
28.6 |
|
72 |
31.4 |
21.4 |
1000 |
24 |
198 |
69.6 |
|
48 |
158 |
82.9 |
|
72 |
134 |
103 |
1 Based
on dissolved zinc concentration analyzed and the information supplied by
the sponsor that the test
item
contains 14.3% zinc.
2 Corrected for the response in the blank.
Description of key information
The water solubility of naphthenic acids, zinc salts was 31.4-56.3 mg/L at a loading rate of 100 mg/L and 134-198 mg/L at a loading rate of 1000 mg/L. Because of the observed spread, no mean value and therefore no maximum difference could be calculated. It is not expected that more accurate results can be obtained.
Key value for chemical safety assessment
Additional information
Charles River (2018) is a GLP-compliant study following OECD guideline 105 and is considered reliable without restrictions (Klimisch 1). The flask method was applied for the determination of the water solubility of Naphthenic acids, zinc salts. Because of the observed spread, no mean value and therefore no maximum difference could be calculated. It is not expected that more accurate results can be obtained.
Under standard test conditions, it was not feasible to derive a water solubility value. Naphthenic acids, zinc salts is a UVCB consisting of a large number of different constituents. Water solubility values have been predicted for representative structures within the UVCB. The QSAR model WSKOWWIN v 1.42 was used and the study was assigned a reliability score of 2 (Reliable with restrictions) as it is an accepted calculated method. The water solubility predictions of the representative structures of zinc naphthenate were 9.367 E-07 to 979.20 mg/L. The QSAR model WATERNT v 1.01 was also used and the study was assigned a reliability score of 2 (Reliable with restrictions) as it is an accepted calculated method. The water solubility predictions of the representative constituents of zinc naphthenate are in the range of 3.1 E-7 - 2645 mg/L.
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