4-Hydroxy-3,5-dimethylbenzonitrile

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 - 27 January 2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Specific details on test material used for the study:

- Lot/batch No.: 00410155
- Analytical purity: 96%
- Expiration date of the lot/batch: 2004-05-05
- Storage condition of test material: At room temperature at about 20°C.

Key result

Water solubility:

0.32 g/L

Conc. based on:

test mat. (dissolved fraction)

Loading of aqueous phase:

1.2 g/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

30 °C

pH:

ca. 5.8

Remarks on result:

other: Equilibration for 24h at 20°C after incubation

Details on results:

The water solubility was not corrected for the purity of the test item .

Sample No.	Shaking time at 30°C	Concentration analysed (mg/L)	Concentration calculated (g/L)	Water solubility calculated (g/L)
1 2	72	62.023 62.802	0.31 0.31	0.32 standard deviation = +/- 0.01
3 4	48	65.037 64.005	0.33 0.32
5 6	24	62.428 62.551	0.31 0.31

Conclusions:

The water solubility of T002251 at 20°C was determined to be 0.32 g/L and thus moderately soluble.

Description of key information

The water solubility of T002251 was determined to be 0.32 g/L at 20°C in a GLP study according to OECD guideline 105 and EU Method A.6 (K1, Tognucci, 2004). T002251 is considered "moderately soluble".

Key value for chemical safety assessment

Water solubility:

0.32 g/L

at the temperature of:

20 °C